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Identification of unique rectal cancer-specific subtypes.

Batuhan Kisakol | Anna Matveeva | Manuela Salvucci | Alexander Kel | Elizabeth McDonough | Fiona Ginty | Daniel B Longley | Jochen H M Prehn
British journal of cancer | 2024

Existing colorectal cancer subtyping methods were generated without much consideration of potential differences in expression profiles between colon and rectal tissues. Moreover, locally advanced rectal cancers at resection often have received neoadjuvant chemoradiotherapy which likely has a significant impact on gene expression.

Pubmed ID: 38532103

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Associated grants

  • Agency: NCI NIH HHS, United States
    Id: R01 CA208179
  • Agency: Science Foundation Ireland (SFI),
    Id: 16/US/3301
  • Agency: Science Foundation Ireland (SFI),
    Id: 18/CRT/6214
  • Agency: EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 Marie SkÅ‚odowska-Curie Actions (H2020 Excellent Science - Marie SkÅ‚odowska-Curie Actions),
    Id: H2020-MSCA-COFUND-2019-945385
  • Agency: U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI),
    Id: R01CA208179
  • Agency: PHA | Health and Social Care Research and Development Division (HCS R&D),
    Id: STL/5715/15

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geneXplain (tool)

RRID:SCR_005573

An online toolbox and workflow management system for a broad range of bioinformatic and systems biology applications. The individual modules, or Bricks, are unified under a standardized interface, with a consistent look-and-feel and can flexibly be put together to comprehensive workflows. The workflow management is intuitively handled through a simple drag-and-drop system. With this system, you can edit the predefined workflows or compose your own workflows from scratch. Your own Bricks can easily be added as scripts or plug-ins and can be used in combination with pre-existing analyses. GeneXplain GmbH provides a number of state-of-the-art bricks; some of them can be obtained free of charge, while others require licensing for small fee in order to guarantee active maintenance and dynamic adaptation to the rapidly developing know-how in this field.

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PROGENY (tool)

RRID:SCR_006647

Fully customizable, comprehensive genetic pedigree and clinical data management software including a multi-user relational database with an integrated pedigree drawing component to manage genetic and pedigree data in one database. Manage Pedigrees, Individuals, SNPs, STRs, Samples, Plates, Genotypes and exports to multiple analysis platforms. (entry from Genetic Analysis Software) * LIMS software, providing advanced sample tracking and management (including functionality to generate and record barcodes) and configurable workflows for your specific environment. * Full genotype management gives users the ability to track not only family-based studies, but Whole Genome Association studies containing 1000''s of samples with large arrays.

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topGO (tool)

RRID:SCR_014798

Software package which provides tools for testing GO terms while accounting for the topology of the GO graph. Different test statistics and different methods for eliminating local similarities and dependencies between GO terms can be implemented and applied.

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