Induced pluripotent stem cell derived pericytes respond to mediators of proliferation and contractility.
Pericytes are multifunctional contractile cells that reside on capillaries. Pericytes are critical regulators of cerebral blood flow and blood-brain barrier function, and pericyte dysfunction may contribute to the pathophysiology of human neurological diseases including Alzheimers disease, multiple sclerosis, and stroke. Induced pluripotent stem cell (iPSC)-derived pericytes (iPericytes) are a promising tool for vascular research. However, it is unclear how iPericytes functionally compare to primary human brain vascular pericytes (HBVPs).
Pubmed ID: 38433209 RIS Download
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Associated grants
- Agency: National Health and Medical Research Council,
Id: APP1137776 - Agency: National Health and Medical Research Council,
Id: APP1163384 - Agency: Medical Research Future Fund,
Id: EPCD000008 - Agency: Multiple Sclerosis Australia,
Id: 19-0696 - Agency: Multiple Sclerosis Australia,
Id: 20-137 - Agency: Multiple Sclerosis Australia,
Id: 21-3-023 - Agency: Multiple Sclerosis Australia,
Id: 22-4-097
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