Peripheral MC1R Activation Modulates Immune Responses and is Neuroprotective in a Mouse Model of Parkinson's Disease.
Melanocortin 1 receptor (MC1R) is a key pigmentation gene, and loss-of-function of MC1R variants that produce red hair may be associated with Parkinson's disease (PD). We previously reported compromised dopaminergic neuron survival in Mc1r mutant mice and dopaminergic neuroprotective effects of local injection of a MC1R agonist to the brain or a systemically administered MC1R agonist with appreciable central nervous system (CNS) permeability. Beyond melanocytes and dopaminergic neurons, MC1R is expressed in other peripheral tissues and cell types, including immune cells. The present study investigates the impact of NDP-MSH, a synthetic melanocortin receptor (MCR) agonist that does not cross BBB, on the immune system and the nigrostriatal dopaminergic system in mouse model of PD.
Pubmed ID: 38110615 RIS Download
Additional research tools detected in this publication
Antibodies used in this publication
- Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 488 (RRID:AB_2576217)
- Brilliant Violet 605(TM) anti-mouse CD25 (RRID:AB_11126977)
- PerCP/Cyanine5.5 anti-mouse CD19 (RRID:AB_2629815)
- Brilliant Violet 510(TM) anti-mouse CD8a (RRID:AB_2563057)
- APC anti-mouse CD4 (RRID:AB_312718)
- Brilliant Violet 785(TM) anti-mouse Ly-6C (RRID:AB_2565852)
- Brilliant Violet 650(TM) anti-mouse Ly-6G (RRID:AB_2565881)
- Brilliant Violet 421(TM) anti-mouse/human CD11b (RRID:AB_11203704)
- Goat Anti-Mouse IgG (whole molecule) Polyclonal Antibody, Biotin Conjugated (RRID:AB_258607)
- Goat Anti-Rabbit IgG Antibody, Biotin Conjugated (RRID:AB_569848)
- Anti-GFAP (RRID:AB_2565444)
- Recombinant Anti-Iba1 antibody [EPR16589] (RRID:AB_2832244)
- Rabbit Anti-Tyrosine hydroxylase Polyclonal Antibody, Unconjugated (RRID:AB_2052772)
- Ultra-LEAF(TM) Purified anti-mouse CD25 (RRID:AB_2813926)
Associated grants
- Agency: NINDS NIH HHS, United States
Id: R01 NS102735 - Agency: NINDS NIH HHS, United States
Id: R01 NS110879 - Agency: NIH HHS, United States
Id: R01NS102735 and R01NS110879
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This is a list of tools and resources that we have found mentioned in this publication.
Goat anti-Rabbit IgG (H+L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor™ 488 (antibody)
RRID:AB_2576217
This polyclonal secondary targets IgG (H+L)
View all literature mentionsBrilliant Violet 605(TM) anti-mouse CD25 (antibody)
RRID:AB_11126977
This monoclonal targets CD25
View all literature mentionsPerCP/Cyanine5.5 anti-mouse CD19 (antibody)
RRID:AB_2629815
This monoclonal targets CD19
View all literature mentionsBrilliant Violet 510(TM) anti-mouse CD8a (antibody)
RRID:AB_2563057
This monoclonal targets CD8a
View all literature mentionsAPC anti-mouse CD4 (antibody)
RRID:AB_312718
This monoclonal targets CD4
View all literature mentionsBrilliant Violet 785(TM) anti-mouse Ly-6C (antibody)
RRID:AB_2565852
This monoclonal targets Ly-6C
View all literature mentionsBrilliant Violet 650(TM) anti-mouse Ly-6G (antibody)
RRID:AB_2565881
This monoclonal targets Ly-6G
View all literature mentionsBrilliant Violet 421(TM) anti-mouse/human CD11b (antibody)
RRID:AB_11203704
This monoclonal targets CD11b
View all literature mentionsGoat Anti-Mouse IgG (whole molecule) Polyclonal Antibody, Biotin Conjugated (antibody)
RRID:AB_258607
This unknown targets Mouse IgG, whole molecule
View all literature mentionsGoat Anti-Rabbit IgG Antibody, Biotin Conjugated (antibody)
RRID:AB_569848
This unknown targets Rabbit IgG
View all literature mentionsRecombinant Anti-Iba1 antibody [EPR16589] (antibody)
RRID:AB_2832244
This recombinant targets Iba1
View all literature mentionsRabbit Anti-Tyrosine hydroxylase Polyclonal Antibody, Unconjugated (antibody)
RRID:AB_2052772
This polyclonal targets Tyrosine hydroxylase
View all literature mentionsUltra-LEAF(TM) Purified anti-mouse CD25 (antibody)
RRID:AB_2813926
This monoclonal targets CD25
View all literature mentionsGraphPad Prism (software resource)
RRID:SCR_002798
Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsFlowJo (software resource)
RRID:SCR_008520
Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.
View all literature mentionsImageJ (software resource)
RRID:SCR_003070
Open source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.
View all literature mentionsEthoVision XT (software resource)
RRID:SCR_000441
Video tracking software that tracks and analyzes the behavior, movement, and activity of any animal.
View all literature mentionsC57BL/6J (organism)
RRID:IMSR_JAX:000664
Mus musculus with name C57BL/6J from IMSR.
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