Engagement of CD99 Activates Distinct Programs in Ewing Sarcoma and Macrophages.
Ewing sarcoma (EWS) is the second most common pediatric bone tumor. The EWS tumor microenvironment is largely recognized as immune-cold, with macrophages being the most abundant immune cells and their presence associated with worse patient prognosis. Expression of CD99 is a hallmark of EWS cells, and its targeting induces inhibition of EWS tumor growth through a poorly understood mechanism. In this study, we analyzed CD99 expression and functions on macrophages and investigated whether the concomitant targeting of CD99 on both tumor and macrophages could explain the inhibitory effect of this approach against EWS. Targeting CD99 on EWS cells downregulated expression of the "don't eat-me" CD47 molecule but increased levels of the "eat-me" phosphatidyl serine and calreticulin molecules on the outer leaflet of the tumor cell membrane, triggering phagocytosis and digestion of EWS cells by macrophages. In addition, CD99 ligation induced reprogramming of undifferentiated M0 macrophages and M2-like macrophages toward the inflammatory M1-like phenotype. These events resulted in the inhibition of EWS tumor growth. Thus, this study reveals what we believe to be a previously unrecognized function of CD99, which engenders a virtuous circle that delivers intrinsic cell death signals to EWS cells, favors tumor cell phagocytosis by macrophages, and promotes the expression of various molecules and cytokines, which are pro-inflammatory and usually associated with tumor regression. This raises the possibility that CD99 may be involved in boosting the antitumor activity of macrophages.
Pubmed ID: 38051221 RIS Download
Research resources used in this publication
- GraphPad Prism (RRID:SCR_002798) (software resource)
- GraphPad Prism (RRID:SCR_002798) (software resource)
- anti-Mouse IgG, peroxidase-linked species-specific F(ab')2 fragment (from sheep) Secondary Antibody, Cytiva (Formerly GE Healthcare Life Sciences) (RRID:AB_772193) (antibody)
- Donkey Anti-Rabbit IgG, Whole Ab ECL Antibody, HRP Conjugated (RRID:AB_772206) (antibody)
- Rabbit Anti-STAT1, CT Polyclonal antibody, Unconjugated (RRID:AB_310145) (antibody)
- Rabbit Anti-GAPDH Monoclonal Antibody, Unconjugated, Clone 14C10 (RRID:AB_561053) (antibody)
- Monoclonal Anti-beta-Tubulin I antibody produced in mouse (RRID:AB_261770) (antibody)
- c-Jun (60A8) Rabbit mAb (RRID:AB_2130165) (antibody)
- c-Fos (9F6) Rabbit mAb (RRID:AB_2247211) (antibody)
- FCS Express (RRID:SCR_016431) (software resource)
- Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb (RRID:AB_10950970) (antibody)
- FCS Express (RRID:SCR_016431) (software resource)
- Calreticulin (CALR) Rabbit anti-Human Monoclonal (Internal) (EPR3924) Antibody (RRID:AB_2069806) (antibody)
- CD47 Antibody, anti-human, PE, REAfinity™ (RRID:AB_2819520) (antibody)
- CD99 Monoclonal Antibody (3B2/TA8), FITC, eBioscience (RRID:AB_2016685) (antibody)
- Bio-Plex Pro Human Cytokine 27-plex Assay (RRID:AB_2893118) (antibody)
- ImageScope (RRID:SCR_014311) (data processing software)
- ImageScope (RRID:SCR_014311) (data processing software)
- Purified CD99 (Ewing's Sarcoma Marker, MIC2) mAb (RRID:AB_2565169) (antibody)
- Anti-Mannose Receptor antibody (RRID:AB_1523910) (antibody)
- F4/80 (D2S9R) XP® Rabbit mAb (RRID:AB_2799771) (antibody)
- Goat Anti-Rabbit IgG (H + L)-HRP Conjugate (RRID:AB_11125142) (antibody)
- Murine IgG1, Kappa Monoclonal Antibody, Control Antibody, Unconjugated, Clone MOPC 21 (RRID:AB_1163632) (antibody)
- MIC2 (12E7) (RRID:AB_629249) (antibody)
- PE/Cyanine7 anti-mouse F4/80 (RRID:AB_893478) (antibody)
- pEGFP-N1-8x (RRID:Addgene_172284) (plasmid)
- Rat Anti-CD16 / CD32 Monoclonal Antibody, Unconjugated, Clone 2.4G2 (RRID:AB_394657) (antibody)
- LAP-35 (RRID:CVCL_A096) (cell line)
- pEGFP-N1-8x (RRID:Addgene_172284) (plasmid)
- LAP-35 (RRID:CVCL_A096) (cell line)
- SK-N-MC (RRID:CVCL_0530) (cell line)
- RD-ES (RRID:CVCL_2169) (cell line)
- RD-ES (RRID:CVCL_2169) (cell line)
- A-673 (RRID:CVCL_0080) (cell line)
- TC-71 (RRID:CVCL_2213) (cell line)
- SK-N-MC (RRID:CVCL_0530) (cell line)
- A-673 (RRID:CVCL_0080) (cell line)
- TC-71 (RRID:CVCL_2213) (cell line)
- SK-ES-1 (RRID:CVCL_0627) (cell line)
- 6647 (RRID:CVCL_H722) (cell line)
- GraphPad Prism (RRID:SCR_002798) (software resource)
- anti-Mouse IgG, peroxidase-linked species-specific F(ab')2 fragment (from sheep) Secondary Antibody, Cytiva (Formerly GE Healthcare Life Sciences) (RRID:AB_772193) (antibody)
- Donkey Anti-Rabbit IgG, Whole Ab ECL Antibody, HRP Conjugated (RRID:AB_772206) (antibody)
- Rabbit Anti-STAT1, CT Polyclonal antibody, Unconjugated (RRID:AB_310145) (antibody)
- Rabbit Anti-GAPDH Monoclonal Antibody, Unconjugated, Clone 14C10 (RRID:AB_561053) (antibody)
- Monoclonal Anti-beta-Tubulin I antibody produced in mouse (RRID:AB_261770) (antibody)
- c-Jun (60A8) Rabbit mAb (RRID:AB_2130165) (antibody)
- c-Fos (9F6) Rabbit mAb (RRID:AB_2247211) (antibody)
- Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb (RRID:AB_10950970) (antibody)
- FCS Express (RRID:SCR_016431) (software resource)
- Calreticulin (CALR) Rabbit anti-Human Monoclonal (Internal) (EPR3924) Antibody (RRID:AB_2069806) (antibody)
- CD47 Antibody, anti-human, PE, REAfinity™ (RRID:AB_2819520) (antibody)
- CD99 Monoclonal Antibody (3B2/TA8), FITC, eBioscience (RRID:AB_2016685) (antibody)
- Bio-Plex Pro Human Cytokine 27-plex Assay (RRID:AB_2893118) (antibody)
- ImageScope (RRID:SCR_014311) (data processing software)
- Purified CD99 (Ewing's Sarcoma Marker, MIC2) mAb (RRID:AB_2565169) (antibody)
- Anti-Mannose Receptor antibody (RRID:AB_1523910) (antibody)
- F4/80 (D2S9R) XP® Rabbit mAb (RRID:AB_2799771) (antibody)
- Goat Anti-Rabbit IgG (H + L)-HRP Conjugate (RRID:AB_11125142) (antibody)
- Murine IgG1, Kappa Monoclonal Antibody, Control Antibody, Unconjugated, Clone MOPC 21 (RRID:AB_1163632) (antibody)
- MIC2 (12E7) (RRID:AB_629249) (antibody)
- PE/Cyanine7 anti-mouse F4/80 (RRID:AB_893478) (antibody)
- Rat Anti-CD16 / CD32 Monoclonal Antibody, Unconjugated, Clone 2.4G2 (RRID:AB_394657) (antibody)
- pEGFP-N1-8x (RRID:Addgene_172284) (plasmid)
- LAP-35 (RRID:CVCL_A096) (cell line)
- RD-ES (RRID:CVCL_2169) (cell line)
- SK-N-MC (RRID:CVCL_0530) (cell line)
- A-673 (RRID:CVCL_0080) (cell line)
- TC-71 (RRID:CVCL_2213) (cell line)
Additional research tools detected in this publication
Antibodies used in this publication
- anti-Mouse IgG, peroxidase-linked species-specific F(ab')2 fragment (from sheep) Secondary Antibody, Cytiva (Formerly GE Healthcare Life Sciences) (RRID:AB_772193)
- Donkey Anti-Rabbit IgG, Whole Ab ECL Antibody, HRP Conjugated (RRID:AB_772206)
- Rabbit Anti-STAT1, CT Polyclonal antibody, Unconjugated (RRID:AB_310145)
- Rabbit Anti-GAPDH Monoclonal Antibody, Unconjugated, Clone 14C10 (RRID:AB_561053)
- Monoclonal Anti-beta-Tubulin I antibody produced in mouse (RRID:AB_261770)
- c-Jun (60A8) Rabbit mAb (RRID:AB_2130165)
- c-Fos (9F6) Rabbit mAb (RRID:AB_2247211)
- Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb (RRID:AB_10950970)
- Calreticulin (CALR) Rabbit anti-Human Monoclonal (Internal) (EPR3924) Antibody (RRID:AB_2069806)
- CD47 Antibody, anti-human, PE, REAfinity™ (RRID:AB_2819520)
- CD99 Monoclonal Antibody (3B2/TA8), FITC, eBioscience (RRID:AB_2016685)
- Bio-Plex Pro Human Cytokine 27-plex Assay (RRID:AB_2893118)
- Purified CD99 (Ewing's Sarcoma Marker, MIC2) mAb (RRID:AB_2565169)
- Anti-Mannose Receptor antibody (RRID:AB_1523910)
- F4/80 (D2S9R) XP® Rabbit mAb (RRID:AB_2799771)
- Goat Anti-Rabbit IgG (H + L)-HRP Conjugate (RRID:AB_11125142)
- Murine IgG1, Kappa Monoclonal Antibody, Control Antibody, Unconjugated, Clone MOPC 21 (RRID:AB_1163632)
- MIC2 (12E7) (RRID:AB_629249)
- PE/Cyanine7 anti-mouse F4/80 (RRID:AB_893478)
- Rat Anti-CD16 / CD32 Monoclonal Antibody, Unconjugated, Clone 2.4G2 (RRID:AB_394657)
Associated grants
- Agency: Fondazione AIRC per la ricerca sul cancro ETS (AIRC),
Id: IG2016-18451 - Agency: Fondazione AIRC per la ricerca sul cancro ETS (AIRC),
Id: IG2019–
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This is a list of tools and resources that we have found mentioned in this publication.
Miltenyi Biotec (tool)
RRID:SCR_008984
An Organization portal, Antibody supplier, Service resource,
View all literature mentionsanti-Mouse IgG, peroxidase-linked species-specific F(ab')2 fragment (from sheep) Secondary Antibody, Cytiva (Formerly GE Healthcare Life Sciences) (antibody)
RRID:AB_772193
This unknown targets
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RRID:AB_772206
This unknown targets IgG
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RRID:AB_310145
This polyclonal targets STAT1, CT
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RRID:AB_561053
This recombinant monoclonal targets GAPDH
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RRID:AB_261770
This monoclonal targets beta-Tubulin I antibody produced in mouse
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RRID:AB_2130165
This monoclonal targets JUND
View all literature mentionsc-Fos (9F6) Rabbit mAb (antibody)
RRID:AB_2247211
This monoclonal targets c-Fos
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RRID:AB_10950970
This monoclonal targets Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb
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RRID:AB_2069806
This monoclonal targets CALR
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RRID:AB_2819520
This recombinant monoclonal targets CD47
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RRID:AB_2016685
This monoclonal targets CD99
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RRID:AB_2893118
This unknown targets Cytokines
View all literature mentionsPurified CD99 (Ewing's Sarcoma Marker, MIC2) mAb (antibody)
RRID:AB_2565169
This monoclonal targets CD99
View all literature mentionsAnti-Mannose Receptor antibody (antibody)
RRID:AB_1523910
This polyclonal targets Mannose Receptor
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RRID:AB_2799771
This recombinant monoclonal targets EMR1
View all literature mentionsGoat Anti-Rabbit IgG (H + L)-HRP Conjugate (antibody)
RRID:AB_11125142
This polyclonal secondary targets IgG (H+L)
View all literature mentionsMurine IgG1, Kappa Monoclonal Antibody, Control Antibody, Unconjugated, Clone MOPC 21 (antibody)
RRID:AB_1163632
This monoclonal targets Murine IgG1 Kappa Control Clone MOPC 21
View all literature mentionsMIC2 (12E7) (antibody)
RRID:AB_629249
This monoclonal targets Human CD99
View all literature mentionsPE/Cyanine7 anti-mouse F4/80 (antibody)
RRID:AB_893478
This monoclonal targets F4/80
View all literature mentionsRat Anti-CD16 / CD32 Monoclonal Antibody, Unconjugated, Clone 2.4G2 (antibody)
RRID:AB_394657
This monoclonal targets CD16 / CD32
View all literature mentionsGraphPad Prism (software resource)
RRID:SCR_002798
Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsGraphPad Prism (software resource)
RRID:SCR_002798
Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsanti-Mouse IgG, peroxidase-linked species-specific F(ab')2 fragment (from sheep) Secondary Antibody, Cytiva (Formerly GE Healthcare Life Sciences) (antibody)
RRID:AB_772193
This unknown targets
View all literature mentionsDonkey Anti-Rabbit IgG, Whole Ab ECL Antibody, HRP Conjugated (antibody)
RRID:AB_772206
This unknown targets IgG
View all literature mentionsRabbit Anti-STAT1, CT Polyclonal antibody, Unconjugated (antibody)
RRID:AB_310145
This polyclonal targets STAT1, CT
View all literature mentionsRabbit Anti-GAPDH Monoclonal Antibody, Unconjugated, Clone 14C10 (antibody)
RRID:AB_561053
This recombinant monoclonal targets GAPDH
View all literature mentionsMonoclonal Anti-beta-Tubulin I antibody produced in mouse (antibody)
RRID:AB_261770
This monoclonal targets beta-Tubulin I antibody produced in mouse
View all literature mentionsc-Jun (60A8) Rabbit mAb (antibody)
RRID:AB_2130165
This monoclonal targets JUND
View all literature mentionsc-Fos (9F6) Rabbit mAb (antibody)
RRID:AB_2247211
This monoclonal targets c-Fos
View all literature mentionsFCS Express (software resource)
RRID:SCR_016431
Software tool for flow and image cytometry data analysis by De Novo Software company.
View all literature mentionsPhospho-Stat1 (Tyr701) (D4A7) Rabbit mAb (antibody)
RRID:AB_10950970
This monoclonal targets Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb
View all literature mentionsFCS Express (software resource)
RRID:SCR_016431
Software tool for flow and image cytometry data analysis by De Novo Software company.
View all literature mentionsCalreticulin (CALR) Rabbit anti-Human Monoclonal (Internal) (EPR3924) Antibody (antibody)
RRID:AB_2069806
This monoclonal targets CALR
View all literature mentionsCD47 Antibody, anti-human, PE, REAfinity™ (antibody)
RRID:AB_2819520
This recombinant monoclonal targets CD47
View all literature mentionsCD99 Monoclonal Antibody (3B2/TA8), FITC, eBioscience (antibody)
RRID:AB_2016685
This monoclonal targets CD99
View all literature mentionsBio-Plex Pro Human Cytokine 27-plex Assay (antibody)
RRID:AB_2893118
This unknown targets Cytokines
View all literature mentionsImageScope (data processing software)
RRID:SCR_014311
Slide image modification software that allows the user to adjust the magnification, compare slides, pan and zoom, annotate specific areas, and perform image analysis of digital slides. Users can create macros and algorithms to automate analysis and create plots, respectively.
View all literature mentionsImageScope (data processing software)
RRID:SCR_014311
Slide image modification software that allows the user to adjust the magnification, compare slides, pan and zoom, annotate specific areas, and perform image analysis of digital slides. Users can create macros and algorithms to automate analysis and create plots, respectively.
View all literature mentionsPurified CD99 (Ewing's Sarcoma Marker, MIC2) mAb (antibody)
RRID:AB_2565169
This monoclonal targets CD99
View all literature mentionsAnti-Mannose Receptor antibody (antibody)
RRID:AB_1523910
This polyclonal targets Mannose Receptor
View all literature mentionsF4/80 (D2S9R) XP® Rabbit mAb (antibody)
RRID:AB_2799771
This recombinant monoclonal targets EMR1
View all literature mentionsGoat Anti-Rabbit IgG (H + L)-HRP Conjugate (antibody)
RRID:AB_11125142
This polyclonal secondary targets IgG (H+L)
View all literature mentionsMurine IgG1, Kappa Monoclonal Antibody, Control Antibody, Unconjugated, Clone MOPC 21 (antibody)
RRID:AB_1163632
This monoclonal targets Murine IgG1 Kappa Control Clone MOPC 21
View all literature mentionsMIC2 (12E7) (antibody)
RRID:AB_629249
This monoclonal targets Human CD99
View all literature mentionsPE/Cyanine7 anti-mouse F4/80 (antibody)
RRID:AB_893478
This monoclonal targets F4/80
View all literature mentionsRat Anti-CD16 / CD32 Monoclonal Antibody, Unconjugated, Clone 2.4G2 (antibody)
RRID:AB_394657
This monoclonal targets CD16 / CD32
View all literature mentionsLAP-35 (cell line)
RRID:CVCL_A096
Cell line LAP-35 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsLAP-35 (cell line)
RRID:CVCL_A096
Cell line LAP-35 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsSK-N-MC (cell line)
RRID:CVCL_0530
Cell line SK-N-MC is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsRD-ES (cell line)
RRID:CVCL_2169
Cell line RD-ES is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsRD-ES (cell line)
RRID:CVCL_2169
Cell line RD-ES is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsA-673 (cell line)
RRID:CVCL_0080
Cell line A-673 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsTC-71 (cell line)
RRID:CVCL_2213
Cell line TC-71 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsSK-N-MC (cell line)
RRID:CVCL_0530
Cell line SK-N-MC is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsA-673 (cell line)
RRID:CVCL_0080
Cell line A-673 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsTC-71 (cell line)
RRID:CVCL_2213
Cell line TC-71 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsSK-ES-1 (cell line)
RRID:CVCL_0627
Cell line SK-ES-1 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentions6647 (cell line)
RRID:CVCL_H722
Cell line 6647 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsGraphPad Prism (software resource)
RRID:SCR_002798
Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsanti-Mouse IgG, peroxidase-linked species-specific F(ab')2 fragment (from sheep) Secondary Antibody, Cytiva (Formerly GE Healthcare Life Sciences) (antibody)
RRID:AB_772193
This unknown targets
View all literature mentionsDonkey Anti-Rabbit IgG, Whole Ab ECL Antibody, HRP Conjugated (antibody)
RRID:AB_772206
This unknown targets IgG
View all literature mentionsRabbit Anti-STAT1, CT Polyclonal antibody, Unconjugated (antibody)
RRID:AB_310145
This polyclonal targets STAT1, CT
View all literature mentionsRabbit Anti-GAPDH Monoclonal Antibody, Unconjugated, Clone 14C10 (antibody)
RRID:AB_561053
This recombinant monoclonal targets GAPDH
View all literature mentionsMonoclonal Anti-beta-Tubulin I antibody produced in mouse (antibody)
RRID:AB_261770
This monoclonal targets beta-Tubulin I antibody produced in mouse
View all literature mentionsc-Jun (60A8) Rabbit mAb (antibody)
RRID:AB_2130165
This monoclonal targets JUND
View all literature mentionsc-Fos (9F6) Rabbit mAb (antibody)
RRID:AB_2247211
This monoclonal targets c-Fos
View all literature mentionsPhospho-Stat1 (Tyr701) (D4A7) Rabbit mAb (antibody)
RRID:AB_10950970
This monoclonal targets Phospho-Stat1 (Tyr701) (D4A7) Rabbit mAb
View all literature mentionsFCS Express (software resource)
RRID:SCR_016431
Software tool for flow and image cytometry data analysis by De Novo Software company.
View all literature mentionsCalreticulin (CALR) Rabbit anti-Human Monoclonal (Internal) (EPR3924) Antibody (antibody)
RRID:AB_2069806
This monoclonal targets CALR
View all literature mentionsCD47 Antibody, anti-human, PE, REAfinity™ (antibody)
RRID:AB_2819520
This recombinant monoclonal targets CD47
View all literature mentionsCD99 Monoclonal Antibody (3B2/TA8), FITC, eBioscience (antibody)
RRID:AB_2016685
This monoclonal targets CD99
View all literature mentionsBio-Plex Pro Human Cytokine 27-plex Assay (antibody)
RRID:AB_2893118
This unknown targets Cytokines
View all literature mentionsImageScope (data processing software)
RRID:SCR_014311
Slide image modification software that allows the user to adjust the magnification, compare slides, pan and zoom, annotate specific areas, and perform image analysis of digital slides. Users can create macros and algorithms to automate analysis and create plots, respectively.
View all literature mentionsPurified CD99 (Ewing's Sarcoma Marker, MIC2) mAb (antibody)
RRID:AB_2565169
This monoclonal targets CD99
View all literature mentionsAnti-Mannose Receptor antibody (antibody)
RRID:AB_1523910
This polyclonal targets Mannose Receptor
View all literature mentionsF4/80 (D2S9R) XP® Rabbit mAb (antibody)
RRID:AB_2799771
This recombinant monoclonal targets EMR1
View all literature mentionsGoat Anti-Rabbit IgG (H + L)-HRP Conjugate (antibody)
RRID:AB_11125142
This polyclonal secondary targets IgG (H+L)
View all literature mentionsMurine IgG1, Kappa Monoclonal Antibody, Control Antibody, Unconjugated, Clone MOPC 21 (antibody)
RRID:AB_1163632
This monoclonal targets Murine IgG1 Kappa Control Clone MOPC 21
View all literature mentionsMIC2 (12E7) (antibody)
RRID:AB_629249
This monoclonal targets Human CD99
View all literature mentionsPE/Cyanine7 anti-mouse F4/80 (antibody)
RRID:AB_893478
This monoclonal targets F4/80
View all literature mentionsRat Anti-CD16 / CD32 Monoclonal Antibody, Unconjugated, Clone 2.4G2 (antibody)
RRID:AB_394657
This monoclonal targets CD16 / CD32
View all literature mentionsLAP-35 (cell line)
RRID:CVCL_A096
Cell line LAP-35 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsRD-ES (cell line)
RRID:CVCL_2169
Cell line RD-ES is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsSK-N-MC (cell line)
RRID:CVCL_0530
Cell line SK-N-MC is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsA-673 (cell line)
RRID:CVCL_0080
Cell line A-673 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentionsTC-71 (cell line)
RRID:CVCL_2213
Cell line TC-71 is a Cancer cell line with a species of origin Homo sapiens (Human)
View all literature mentions
