Inhibition of PRL2 Upregulates PTEN and Attenuates Tumor Growth in Tp53-deficient Sarcoma and Lymphoma Mouse Models.

Cell Signaling Technology (tool)

RRID:SCR_002071

Privately held company that develops and produces antibodies, ELISA kits, ChIP kits, proteomic kits, and other related reagents used to study cell signaling pathways that impact human health.

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Promega (tool)

RRID:SCR_006724

An Antibody supplier

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Santa Cruz Biotechnology (tool)

RRID:SCR_008987

An Antibody supplier

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Abcam (tool)

RRID:SCR_012931

A commercial antibody supplier which supplies primary and secondary antibodies, biochemicals, proteins, peptides, lysates, immunoassays and other kits.

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C57BL/6J (tool)

RRID:IMSR_JAX:000664

Mus musculus with name C57BL/6J from IMSR.

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Anti-PCNA antibody [PC10] (antibody)

RRID:AB_303394

This monoclonal targets PCNA

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Anti-mouse IgG, HRP-linked Antibody (antibody)

RRID:AB_330924

This polyclonal targets IgG

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Anti-rabbit IgG, HRP-linked Antibody (antibody)

RRID:AB_2099233

This polyclonal secondary targets IgG

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Novocastra™ Liquid Rabbit Polyclonal Antibody p53 Protein (CM5) (antibody)

RRID:AB_2895247

This polyclonal targets p53 protein

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PUMA alpha Polyclonal Antibody (antibody)

RRID:AB_11153580

This unknown targets PUMA alpha

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p-4E-BP1/2/3 (A-10) (antibody)

RRID:AB_10709575

This monoclonal targets p-4E-BP1/2/3 (A-10)

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4E-BP1 (P-1) (antibody)

RRID:AB_626621

This monoclonal targets 4E-BP1 (P-1)

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cyclin D1 (DCS-6) (antibody)

RRID:AB_627346

This monoclonal targets CCND1

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Mouse Anti-P21 Monoclonal antibody, Unconjugated, Clone f-5 (antibody)

RRID:AB_628073

This monoclonal targets CDKN1A

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Rabbit Anti-P27 Polyclonal antibody, Unconjugated (antibody)

RRID:AB_632129

This polyclonal targets CDKN1B

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Bax Antibody (antibody)

RRID:AB_10695870

This polyclonal targets Bax

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Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204) (D13.14.4E) XP® Rabbit mAb (antibody)

RRID:AB_2315112

This monoclonal targets Phospho-p44/42 MAPK (Erk1/2) (Thr202/Tyr204)

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Mouse Anti-p44 / 42 MAP Kinase Monoclonal Antibody, Unconjugated, Clone L34F12 (antibody)

RRID:AB_390780

This monoclonal targets p44 / 42 MAP Kinase

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Phospho-GSK-3alpha/beta (Ser21/9) Antibody (antibody)

RRID:AB_329830

This polyclonal targets Phospho-GSK-3alpha/beta (Ser21/9)

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GSK-3alpha/beta (D75D3) XP Rabbit mAb (antibody)

RRID:AB_10547140

This monoclonal targets GSK-3alpha/beta

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Phospho-FoxO1 (Thr24)/FoxO3a (Thr32)/FoxO4 (Thr28) (4G6) Rabbit mAb (antibody)

RRID:AB_2106814

This monoclonal targets FOXO3

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FoxO1 (C29H4) Rabbit mAb (antibody)

RRID:AB_2106495

This monoclonal targets FoxO1 (C29H4) Rabbit mAb

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PCNA (PC10) Mouse mAb (antibody)

RRID:AB_2160343

This monoclonal targets PCNA

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Phospho-Bad (Ser136) (D25H8) Rabbit mAb (antibody)

RRID:AB_10547878

This monoclonal targets Phospho-Bad (Ser136) (D25H8) Rabbit mAb

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Caspase-3 (D3R6Y) Rabbit mAb (antibody)

RRID:AB_2798429

This monoclonal targets CASP3

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PARP Antibody (antibody)

RRID:AB_2160739

This polyclonal targets PARP

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Anti-β-Actin Antibody (C4) (antibody)

RRID:AB_626632

This monoclonal targets β-Actin

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Phospho-mTOR (Ser2448) Antibody (antibody)

RRID:AB_330970

This polyclonal targets Phospho-mTOR (Ser2448)

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Anti-mTOR Antibody, Unconjugated (antibody)

RRID:AB_330978

This unknown targets mTOR

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Phospho-Akt (Ser473) (D9E) XP® Rabbit mAb (antibody)

RRID:AB_2315049

This monoclonal targets Phospho-Akt (Ser473)

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Akt Antibody (antibody)

RRID:AB_329827

This polyclonal targets Akt

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PTEN (D4.3) XP Rabbit mAb (antibody)

RRID:AB_2253290

This monoclonal targets PTEN (D4.3) XP Rabbit mAb

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Brilliant Violet 421(TM) anti-mouse/human CD44 (antibody)

RRID:AB_10895752

This monoclonal targets CD44

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Brilliant Violet 605(TM) anti-mouse CD25 (antibody)

RRID:AB_11126977

This monoclonal targets CD25

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PE/Cyanine7 anti-mouse CD45 (antibody)

RRID:AB_312979

This monoclonal targets CD45

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PE anti-mouse CD8a (antibody)

RRID:AB_312747

This monoclonal targets CD8a

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Alexa Fluor(R) 488 anti-mouse CD4 (antibody)

RRID:AB_389302

This monoclonal targets CD4

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Microsoft Excel (software resource)

RRID:SCR_016137

Software application with data analysis tools and spreadsheet templates to track and visualize data. It is used to manage and process data.

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Open source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.

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The Cancer Genome Atlas (biomaterial supply resource)

RRID:SCR_003193

Project exploring the spectrum of genomic changes involved in more than 20 types of human cancer that provides a platform for researchers to search, download, and analyze data sets generated. As a pilot project it confirmed that an atlas of changes could be created for specific cancer types. It also showed that a national network of research and technology teams working on distinct but related projects could pool the results of their efforts, create an economy of scale and develop an infrastructure for making the data publicly accessible. Its success committed resources to collect and characterize more than 20 additional tumor types. Components of the TCGA Research Network: * Biospecimen Core Resource (BCR); Tissue samples are carefully cataloged, processed, checked for quality and stored, complete with important medical information about the patient. * Genome Characterization Centers (GCCs); Several technologies will be used to analyze genomic changes involved in cancer. The genomic changes that are identified will be further studied by the Genome Sequencing Centers. * Genome Sequencing Centers (GSCs); High-throughput Genome Sequencing Centers will identify the changes in DNA sequences that are associated with specific types of cancer. * Proteome Characterization Centers (PCCs); The centers, a component of NCI's Clinical Proteomic Tumor Analysis Consortium, will ascertain and analyze the total proteomic content of a subset of TCGA samples. * Data Coordinating Center (DCC); The information that is generated by TCGA will be centrally managed at the DCC and entered into the TCGA Data Portal and Cancer Genomics Hub as it becomes available. Centralization of data facilitates data transfer between the network and the research community, and makes data analysis more efficient. The DCC manages the TCGA Data Portal. * Cancer Genomics Hub (CGHub); Lower level sequence data will be deposited into a secure repository. This database stores cancer genome sequences and alignments. * Genome Data Analysis Centers (GDACs) - Immense amounts of data from array and second-generation sequencing technologies must be integrated across thousands of samples. These centers will provide novel informatics tools to the entire research community to facilitate broader use of TCGA data. TCGA is actively developing a network of collaborators who are able to provide samples that are collected retrospectively (tissues that had already been collected and stored) or prospectively (tissues that will be collected in the future).

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FlowJo (software resource)

RRID:SCR_008520

Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.

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B6.129P2-Trp53^tm1Brn/J (organism)

RRID:IMSR_JAX:008462

Mus musculus with name B6.129P2-Trp53^tm1Brn/J from IMSR.

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B6.129-Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/J (organism)

RRID:IMSR_JAX:008463

Mus musculus with name B6.129-Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/J from IMSR.

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Microsoft Excel (software resource)

RRID:SCR_016137

Software application with data analysis tools and spreadsheet templates to track and visualize data. It is used to manage and process data.

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ImageJ (software resource)

RRID:SCR_003070

Open source Java based image processing software program designed for scientific multidimensional images. ImageJ has been transformed to ImageJ2 application to improve data engine to be sufficient to analyze modern datasets.

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The Cancer Genome Atlas (biomaterial supply resource)

RRID:SCR_003193

Project exploring the spectrum of genomic changes involved in more than 20 types of human cancer that provides a platform for researchers to search, download, and analyze data sets generated. As a pilot project it confirmed that an atlas of changes could be created for specific cancer types. It also showed that a national network of research and technology teams working on distinct but related projects could pool the results of their efforts, create an economy of scale and develop an infrastructure for making the data publicly accessible. Its success committed resources to collect and characterize more than 20 additional tumor types. Components of the TCGA Research Network: * Biospecimen Core Resource (BCR); Tissue samples are carefully cataloged, processed, checked for quality and stored, complete with important medical information about the patient. * Genome Characterization Centers (GCCs); Several technologies will be used to analyze genomic changes involved in cancer. The genomic changes that are identified will be further studied by the Genome Sequencing Centers. * Genome Sequencing Centers (GSCs); High-throughput Genome Sequencing Centers will identify the changes in DNA sequences that are associated with specific types of cancer. * Proteome Characterization Centers (PCCs); The centers, a component of NCI's Clinical Proteomic Tumor Analysis Consortium, will ascertain and analyze the total proteomic content of a subset of TCGA samples. * Data Coordinating Center (DCC); The information that is generated by TCGA will be centrally managed at the DCC and entered into the TCGA Data Portal and Cancer Genomics Hub as it becomes available. Centralization of data facilitates data transfer between the network and the research community, and makes data analysis more efficient. The DCC manages the TCGA Data Portal. * Cancer Genomics Hub (CGHub); Lower level sequence data will be deposited into a secure repository. This database stores cancer genome sequences and alignments. * Genome Data Analysis Centers (GDACs) - Immense amounts of data from array and second-generation sequencing technologies must be integrated across thousands of samples. These centers will provide novel informatics tools to the entire research community to facilitate broader use of TCGA data. TCGA is actively developing a network of collaborators who are able to provide samples that are collected retrospectively (tissues that had already been collected and stored) or prospectively (tissues that will be collected in the future).

View all literature mentions

FlowJo (software resource)

RRID:SCR_008520

Software for single-cell flow cytometry analysis. Its functions include management, display, manipulation, analysis and publication of the data stream produced by flow and mass cytometers.

View all literature mentions