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Conjugated Estrogens and Bazedoxifene Improve β Cell Function in Obese Menopausal Women.

Dragana Lovre | Erin Peacock | Bonnie Katalenich | Cynthia Moreau | Beibei Xu | Chandra Tate | Kristina M Utzschneider | Jean-François Gautier | Vivian Fonseca | Franck Mauvais-Jarvis
Journal of the Endocrine Society | 2019

Studies suggest that menopausal hormone therapy (MHT) prevents type 2 diabetes (T2D). The combination of conjugated estrogens (CE) with the selective estrogen receptor modulator bazedoxifene (BZA) is an MHT that improves obesity and T2D in preclinical models of menopausal metabolic syndrome. The effect of CE/BZA on adiposity and glucose homeostasis in obese postmenopausal women is unknown.

Pubmed ID: 31384719 RIS Download

Associated grants

  • Agency: BLRD VA, United States
    Id: I01 BX003725
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK074970
  • Agency: NICHD NIH HHS, United States
    Id: K12 HD043451
  • Agency: NIGMS NIH HHS, United States
    Id: U54 GM104940
  • Agency: NIDDK NIH HHS, United States
    Id: R01 DK107444
  • Agency: NIDDK NIH HHS, United States
    Id: P30 DK017047

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