Stimulation of Hair Growth by Small Molecules that Activate Autophagy.
Hair plays important roles, ranging from the conservation of body heat to the preservation of psychological well-being. Hair loss or alopecia affects millions worldwide, but methods that can be used to regrow hair are lacking. We report that quiescent (telogen) hair follicles can be stimulated to initiate anagen and hair growth by small molecules that activate autophagy, including the metabolites α-ketoglutarate (α-KG) and α-ketobutyrate (α-KB), and the prescription drugs rapamycin and metformin, which impinge on mTOR and AMPK signaling. Stimulation of hair growth by these agents is blocked by specific autophagy inhibitors, suggesting a mechanistic link between autophagy and hair regeneration. Consistently, increased autophagy is detected upon anagen entry during the natural hair follicle cycle, and oral α-KB prevents hair loss in aged mice. Our finding that anagen can be pharmacologically activated in telogen skin when natural anagen-inducing signal(s) are absent has implications for the treatment of hair loss patients.
Pubmed ID: 31216464 RIS Download
Research resources used in this publication
Additional research tools detected in this publication
None foundAntibodies used in this publication
- Recombinant Anti-Beclin 1 antibody [EPR19662] (RRID:AB_2692326)
- GAPDH Monoclonal Antibody (6C5) (RRID:AB_2536381)
- Rabbit Anti-p62 / SQSTM1 Antibody, Unconjugated (RRID:AB_1841066)
- Phospho-Beclin-1 (Ser15) (D4B7R) Rabbit mAb (RRID:AB_2800045)
- Rat Anti-Mouse F4/80 ANTIGEN Monoclonal antibody, Unconjugated, Clone CI:A3-1 (RRID:AB_872005)
- Anti-Phospho-Beclin-1 (Ser93) (D9A5G) Rabbit Antibody (RRID:AB_2688032)
- Ki-67 (D3B5) Rabbit mAb (Mouse Preferred; IHC Formulated) (RRID:AB_2620142)
- IL6 antibody (RRID:AB_2127460)
- LC3B Antibody (RRID:AB_10003146)
Associated grants
- Agency: NHLBI NIH HHS, United States
Id: P01 HL090553
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This is a list of tools and resources that we have found mentioned in this publication.
Recombinant Anti-Beclin 1 antibody [EPR19662] (antibody)
RRID:AB_2692326
This recombinant monoclonal targets Beclin 1
View all literature mentionsGAPDH Monoclonal Antibody (6C5) (antibody)
RRID:AB_2536381
This monoclonal targets GAPDH
View all literature mentionsRabbit Anti-p62 / SQSTM1 Antibody, Unconjugated (antibody)
RRID:AB_1841066
This unknown targets p62 / SQSTM1
View all literature mentionsPhospho-Beclin-1 (Ser15) (D4B7R) Rabbit mAb (antibody)
RRID:AB_2800045
This monoclonal targets beclin 1
View all literature mentionsRat Anti-Mouse F4/80 ANTIGEN Monoclonal antibody, Unconjugated, Clone CI:A3-1 (antibody)
RRID:AB_872005
This monoclonal targets Mouse F4/80 ANTIGEN
View all literature mentionsAnti-Phospho-Beclin-1 (Ser93) (D9A5G) Rabbit Antibody (antibody)
RRID:AB_2688032
This monoclonal targets Phospho-Beclin-1 (Ser93)
View all literature mentionsKi-67 (D3B5) Rabbit mAb (Mouse Preferred; IHC Formulated) (antibody)
RRID:AB_2620142
This monoclonal targets Ki-67
View all literature mentionsMicrosoft Excel (software resource)
RRID:SCR_016137
Software application with data analysis tools and spreadsheet templates to track and visualize data. It is used to manage and process data.
View all literature mentionsGraphPad Prism (software resource)
RRID:SCR_002798
Statistical analysis software that combines scientific graphing, comprehensive curve fitting (nonlinear regression), understandable statistics, and data organization. Designed for biological research applications in pharmacology, physiology, and other biological fields for data analysis, hypothesis testing, and modeling.
View all literature mentionsC57BL/6J (organism)
RRID:IMSR_JAX:000664
Mus musculus with name C57BL/6J from IMSR.
View all literature mentions
