URL: https://www.mmrrc.org/catalog/sds.php?mmrrc_id=37395
Proper Citation: RRID:MMRRC_037395-JAX
Description: Mus musculus with name C57BL/6-Flt3ltm1Imx/TacMmjax from MMRRC.
Species: Mus musculus
Notes: Research areas: ; Mutation Type: Targeted Mutation ; Collection:
Phenotype: increased neutrophil cell number [MP:0000219]| decreased leukocyte cell number [MP:0000221]| decreased monocyte cell number [MP:0000223]| decreased bone marrow cell number [MP:0000333]| spleen hypoplasia [MP:0000694]| abnormal immune system cell morphology [MP:0000716]| impaired myelopoiesis [MP:0001602]| abnormal dendritic cell antigen presentation [MP:0002455]| increased IgM level [MP:0002494]| abnormal immune system organ morphology [MP:0002722]| decreased macrophage cell number [MP:0003884]| increased length of allograft survival [MP:0004751]| decreased hematopoietic stem cell number [MP:0004810]| decreased lymphocyte cell number [MP:0005016]| decreased B cell number [MP:0005017]| abnormal immature B cell morphology [MP:0005022]| increased susceptibility to parasitic infection [MP:0005027]| decreased double-negative T cell number [MP:0005089]| abnormal dendritic cell morphology [MP:0005461]| abnormal T-helper 1 physiology [MP:0005465]| abnormal common myeloid progenitor cell morphology [MP:0006410]| decreased NK cell number [MP:0008045]| abnormal memory T cell physiology [MP:0008051]| lymph node hypoplasia [MP:0008101]| decreased myeloid dendritic cell number [MP:0008122]| decreased plasmacytoid dendritic cell number [MP:0008124]| decreased dendritic cell number [MP:0008127]| decreased pro-B cell number [MP:0008208]| decreased pre-B cell number [MP:0008209]| abnormal leukocyte morphology [MP:0008246]| abnormal common lymphocyte progenitor cell morphology [MP:0008249]| abnormal dendritic cell chemotaxis [MP:0010740]| decreased CD11b-high dendritic cell number [MP:0013649]| decreased CD103-positive CD11b-low dendritic cell number [MP:0013655]
Affected Gene: Flt3l
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Source: Integrated Animals
Source Database: Mutant Mouse Resource and Research Center (MMRRC)
