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Proper Citation: RRID:MGI:3618624
Description: Allele Detail: Targeted This is a legacy resource.
Species: Mus musculus
Notes: Allele Detail: Targeted This is a legacy resource.
Phenotype: small pancreatic islets, abnormal insulin secretion, increased liver glycogen level, impaired glucose tolerance, decreased body size, decreased bone mineralization, increased osteoblast apoptosis, postnatal growth retardation, osteoporosis, abnormal compact bone morphology, hyperglycemia, exocrine pancreatic insufficiency, prenatal lethality, incomplete penetrance, abnormal pancreatic alpha cell morphology, abnormal skeleton morphology, decreased pancreatic beta cell number, abnormal pancreatic acinar cell morphology, absent pancreatic alpha cells, postnatal lethality, incomplete penetrance, absent pancreatic beta cells, decreased compact bone thickness, abnormal osteoblast physiology, abnormal osteoblast morphology, abnormal vertebral body morphology, abnormal vertebrae development, decreased circulating insulin level, abnormal hindlimb morphology, hunched posture, hypoactivity, abnormal axial skeleton morphology, decreased pancreatic beta cell number, abnormal exocrine pancreas morphology
Affected Gene: Eif2ak3
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Source: Integrated Animals
Source Database: MGI, Mouse Genome Informatics MGI