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NCI-H2804

RRID:CVCL_U998

Organism

Homo sapiens

Comments

Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Microsatellite instability: Stable (MSS) (Sanger). Omics: Deep exome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: SNP array analysis. Omics: Transcriptome analysis. Genome ancestry: African=1.05%; Native American=0%; East Asian, North=2.06%; East Asian, South=0%; South Asian=0%; European, North=68.14%; European, South=28.74% (PubMed=30894373). DT Created: 16-04-14; Last updated: 05-07-19; Version: 17

Proper Citation

RRID:CVCL_U998

Category

Cancer cell line DT Created: 16-04-14; Last updated: 05-07-19; Version: 17

Sex

DT Created: 16-04-14; Last updated: 05-07-19; Version: 17

Synonyms

H2804, H-2804, NCIH2804 DT Created: 16-04-14, Last updated: 05-07-19, Version: 17

Cross References

EFO; EFO_0006688 ArrayExpress; E-MTAB-2706 ArrayExpress; E-MTAB-3610 BioSample; SAMN03471014 CCLE; NCIH2804_PLEURA Cell_Model_Passport; SIDM00310 Cosmic; 1995416 Cosmic-CLP; 1240136 DepMap; ACH-002132 GDSC; 1240136 GEO; GSM1669827 Wikidata; Q54908004 DT Created: 16-04-14; Last updated: 05-07-19; Version: 17

Hierarchy

DT Created: 16-04-14; Last updated: 05-07-19; Version: 17

Originate from Same Individual

DT Created: 16-04-14; Last updated: 05-07-19; Version: 17

Publications that use this research resource

Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells.

  • Kolluri KK
  • Elife
  • 2018 Jan 18

Literature context:


Abstract:

Malignant mesothelioma (MM) is poorly responsive to systemic cytotoxic chemotherapy and invariably fatal. Here we describe a screen of 94 drugs in 15 exome-sequenced MM lines and the discovery of a subset defined by loss of function of the nuclear deubiquitinase BRCA associated protein-1 (BAP1) that demonstrate heightened sensitivity to TRAIL (tumour necrosis factor-related apoptosis-inducing ligand). This association is observed across human early passage MM cultures, mouse xenografts and human tumour explants. We demonstrate that BAP1 deubiquitinase activity and its association with ASXL1 to form the Polycomb repressive deubiquitinase complex (PR-DUB) impacts TRAIL sensitivity implicating transcriptional modulation as an underlying mechanism. Death receptor agonists are well-tolerated anti-cancer agents demonstrating limited therapeutic benefit in trials without a targeting biomarker. We identify BAP1 loss-of-function mutations, which are frequent in MM, as a potential genomic stratification tool for TRAIL sensitivity with immediate and actionable therapeutic implications.

Funding information:
  • Cancer Research UK - A17341()
  • NINDS NIH HHS - R01NS043915(United States)
  • Wellcome - WT097452MA()
  • Wellcome Trust - 106555/Z/14/Z()
  • Wellcome Trust - WT107963AIA()