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NCI-H2591

RRID:CVCL_A543

Organism

Homo sapiens

Comments

Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Microsatellite instability: Stable (MSS) (Sanger). Omics: Array-based CGH. Omics: Deep exome analysis. Omics: DNA methylation analysis. Omics: Transcriptome analysis. Genome ancestry: African=0%; Native American=0%; East Asian, North=0%; East Asian, South=0.61%; South Asian=1.63%; European, North=68.64%; European, South=29.11% (PubMed=30894373). DT Created: 06-06-12; Last updated: 05-07-19; Version: 20

Proper Citation

RRID:CVCL_A543

Category

Cancer cell line DT Created: 06-06-12; Last updated: 05-07-19; Version: 20

Sex

DT Created: 06-06-12; Last updated: 05-07-19; Version: 20

Synonyms

H2591, H-2591, NCIH2591 DT Created: 06-06-12, Last updated: 05-07-19, Version: 20

Cross References

ArrayExpress; E-MTAB-3610 BioSample; SAMN03471042 CCLE; NCIH2591_PLEURA Cell_Model_Passport; SIDM00101 Cosmic; 1032379 Cosmic-CLP; 1240131 DepMap; ACH-002126 GDSC; 1240131 GEO; GSM1669821 Wikidata; Q54907986 DT Created: 06-06-12; Last updated: 05-07-19; Version: 20

Hierarchy

DT Created: 06-06-12; Last updated: 05-07-19; Version: 20

Originate from Same Individual

DT Created: 06-06-12; Last updated: 05-07-19; Version: 20

Publications that use this research resource

Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells.

  • Kolluri KK
  • Elife
  • 2018 Jan 18

Literature context:


Abstract:

Malignant mesothelioma (MM) is poorly responsive to systemic cytotoxic chemotherapy and invariably fatal. Here we describe a screen of 94 drugs in 15 exome-sequenced MM lines and the discovery of a subset defined by loss of function of the nuclear deubiquitinase BRCA associated protein-1 (BAP1) that demonstrate heightened sensitivity to TRAIL (tumour necrosis factor-related apoptosis-inducing ligand). This association is observed across human early passage MM cultures, mouse xenografts and human tumour explants. We demonstrate that BAP1 deubiquitinase activity and its association with ASXL1 to form the Polycomb repressive deubiquitinase complex (PR-DUB) impacts TRAIL sensitivity implicating transcriptional modulation as an underlying mechanism. Death receptor agonists are well-tolerated anti-cancer agents demonstrating limited therapeutic benefit in trials without a targeting biomarker. We identify BAP1 loss-of-function mutations, which are frequent in MM, as a potential genomic stratification tool for TRAIL sensitivity with immediate and actionable therapeutic implications.

Funding information:
  • Cancer Research UK - A17341()
  • NINDS NIH HHS - R01NS043915(United States)
  • Wellcome - WT097452MA()
  • Wellcome Trust - 106555/Z/14/Z()
  • Wellcome Trust - WT107963AIA()