X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

NCI-H2461

RRID:CVCL_A536

Organism

Homo sapiens

Comments

Part of: Cancer Cell Line Encyclopedia (CCLE) project. Part of: COSMIC cell lines project. Microsatellite instability: Stable (MSS) (Sanger). Omics: Array-based CGH. Omics: Deep exome analysis. Omics: Deep RNAseq analysis. Omics: DNA methylation analysis. Omics: SNP array analysis. Omics: Transcriptome analysis. Genome ancestry: African=0.92%; Native American=0.07%; East Asian, North=1.1%; East Asian, South=1.25%; South Asian=0%; European, North=63.28%; European, South=33.37% (PubMed=30894373). DT Created: 06-06-12; Last updated: 05-07-19; Version: 21

Proper Citation

RRID:CVCL_A536

Category

Cancer cell line DT Created: 06-06-12; Last updated: 05-07-19; Version: 21

Sex

DT Created: 06-06-12; Last updated: 05-07-19; Version: 21

Synonyms

H2461, H-2461, NCIH2461 DT Created: 06-06-12, Last updated: 05-07-19, Version: 21

Cross References

EFO; EFO_0006681 ArrayExpress; E-MTAB-2706 ArrayExpress; E-MTAB-3610 BioSample; SAMN03471038 CCLE; NCIH2461_PLEURA Cell_Model_Passport; SIDM00102 Cosmic; 1032371 Cosmic; 1087353 Cosmic; 1995412 Cosmic-CLP; 1290810 DepMap; ACH-002125 GDSC; 1290810 GEO; GSM1669820 Wikidata; Q54907976 DT Created: 06-06-12; Last updated: 05-07-19; Version: 21

Hierarchy

DT Created: 06-06-12; Last updated: 05-07-19; Version: 21

Originate from Same Individual

DT Created: 06-06-12; Last updated: 05-07-19; Version: 21

Publications that use this research resource

Loss of functional BAP1 augments sensitivity to TRAIL in cancer cells.

  • Kolluri KK
  • Elife
  • 2018 Jan 18

Literature context:


Abstract:

Malignant mesothelioma (MM) is poorly responsive to systemic cytotoxic chemotherapy and invariably fatal. Here we describe a screen of 94 drugs in 15 exome-sequenced MM lines and the discovery of a subset defined by loss of function of the nuclear deubiquitinase BRCA associated protein-1 (BAP1) that demonstrate heightened sensitivity to TRAIL (tumour necrosis factor-related apoptosis-inducing ligand). This association is observed across human early passage MM cultures, mouse xenografts and human tumour explants. We demonstrate that BAP1 deubiquitinase activity and its association with ASXL1 to form the Polycomb repressive deubiquitinase complex (PR-DUB) impacts TRAIL sensitivity implicating transcriptional modulation as an underlying mechanism. Death receptor agonists are well-tolerated anti-cancer agents demonstrating limited therapeutic benefit in trials without a targeting biomarker. We identify BAP1 loss-of-function mutations, which are frequent in MM, as a potential genomic stratification tool for TRAIL sensitivity with immediate and actionable therapeutic implications.

Funding information:
  • Cancer Research UK - A17341()
  • NINDS NIH HHS - R01NS043915(United States)
  • Wellcome - WT097452MA()
  • Wellcome Trust - 106555/Z/14/Z()
  • Wellcome Trust - WT107963AIA()