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R187

RRID:CVCL_9230

Organism

Mus musculus, Rattus norvegicus

Comments

Monoclonal antibody isotype: IgG1. DT Created: 06-06-12; Last updated: 07-09-18; Version: 5

Proper Citation

ATCC Cat# CRL-1912, RRID:CVCL_9230

Category

Hybridoma DT Created: 06-06-12; Last updated: 07-09-18; Version: 5

Sex

DT Created: 06-06-12; Last updated: 07-09-18; Version: 5

Synonyms

DT Created: 06-06-12, Last updated: 07-09-18, Version: 5

Vendor

ATCC

Cat Num

CRL-1912

Cross References

CLO; CLO_0008706 ATCC; CRL-1912 Wikidata; Q54949023 DT Created: 06-06-12; Last updated: 07-09-18; Version: 5

Hierarchy

DT Created: 06-06-12; Last updated: 07-09-18; Version: 5

Originate from Same Individual

DT Created: 06-06-12; Last updated: 07-09-18; Version: 5

Publications that use this research resource

Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors.

  • Blanco-Melo D
  • Elife
  • 2017 Apr 11

Literature context:


Abstract:

Endogenous retroviral sequences provide a molecular fossil record of ancient infections whose analysis might illuminate mechanisms of viral extinction. A close relative of gammaretroviruses, HERV-T, circulated in primates for ~25 million years (MY) before apparent extinction within the past ~8 MY. Construction of a near-complete catalog of HERV-T fossils in primate genomes allowed us to estimate a ~32 MY old ancestral sequence and reconstruct a functional envelope protein (ancHTenv) that could support infection of a pseudotyped modern gammaretrovirus. Using ancHTenv, we identify monocarboxylate transporter-1 (MCT-1) as a receptor used by HERV-T for attachment and infection. A single HERV-T provirus in hominid genomes includes an env gene (hsaHTenv) that has been uniquely preserved. This apparently exapted HERV-T env could not support virion infection but could block ancHTenv mediated infection, by causing MCT-1 depletion from cell surfaces. Thus, hsaHTenv may have contributed to HERV-T extinction, and could also potentially regulate cellular metabolism.