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MT-2

RRID:CVCL_2631

Organism

Homo sapiens

Comments

Characteristics: HTLV-1 producing cell line. Contains 11 integrated HTLV-1 proviruses: one complete proviral genome, six copies of a provirus with an internal deletion of 5.3 kb, one copy of a provirus with an internal deletion of 3.9 kb, one copy of a provirus with a 6.2 kB deletion from 5'LTR to position 6257, and two copies of a provirus composed of LTR only. Characteristics: Susceptible to infection by HCV (PubMed=7832798). Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1). Discontinued: ECACC; 93121518. Discontinued: JCRB; NIHS0527. DT Created: 04-04-12; Last updated: 24-05-19; Version: 18

Proper Citation

ECACC Cat# 08081401, RRID:CVCL_2631

Category

Transformed cell line DT Created: 04-04-12; Last updated: 24-05-19; Version: 18

Sex

DT Created: 04-04-12; Last updated: 24-05-19; Version: 18

Synonyms

MT2, MT-2J DT Created: 04-04-12, Last updated: 24-05-19, Version: 18

Vendor

ECACC

Cat Num

08081401

Cross References

BTO; BTO:0005492 CLO; CLO_0007888 CLDB; cl3596 CLDB; cl3597 BioSample; SAMN03472437 ChEMBL-Cells; CHEMBL3307558 ChEMBL-Targets; CHEMBL614184 Cosmic; 919158 ECACC; 08081401 ECACC; 93121518 JCRB; JCRB1210 JCRB; NIHS0527 NIH-ARP; 237-339 Wikidata; Q54906935 DT Created: 04-04-12; Last updated: 24-05-19; Version: 18

Hierarchy

DT Created: 04-04-12; Last updated: 24-05-19; Version: 18

Originate from Same Individual

DT Created: 04-04-12; Last updated: 24-05-19; Version: 18

Publications that use this research resource

Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors.

  • Blanco-Melo D
  • Elife
  • 2017 Apr 11

Literature context:


Abstract:

Endogenous retroviral sequences provide a molecular fossil record of ancient infections whose analysis might illuminate mechanisms of viral extinction. A close relative of gammaretroviruses, HERV-T, circulated in primates for ~25 million years (MY) before apparent extinction within the past ~8 MY. Construction of a near-complete catalog of HERV-T fossils in primate genomes allowed us to estimate a ~32 MY old ancestral sequence and reconstruct a functional envelope protein (ancHTenv) that could support infection of a pseudotyped modern gammaretrovirus. Using ancHTenv, we identify monocarboxylate transporter-1 (MCT-1) as a receptor used by HERV-T for attachment and infection. A single HERV-T provirus in hominid genomes includes an env gene (hsaHTenv) that has been uniquely preserved. This apparently exapted HERV-T env could not support virion infection but could block ancHTenv mediated infection, by causing MCT-1 depletion from cell surfaces. Thus, hsaHTenv may have contributed to HERV-T extinction, and could also potentially regulate cellular metabolism.