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UMNSAH/DF-1

RRID:CVCL_0570

Organism

Gallus gallus

Comments

Group: Bird cell line. Doubling time: 13.22 hours (in DMEM/F-12 medium), 33.64 hours (in MEM medium), 15.30 hours (in RPMI 1640 medium), 21.39 hours (in DMEM medium) (CelloPub=CLPUB00401). Omics: Transcriptome analysis. Breed/subspecies: East Lansing Line 0 (ELL-0). DT Created: 04-04-12; Last updated: 24-05-19; Version: 16

Proper Citation

BCRJ Cat# 0307, RRID:CVCL_0570

Category

Spontaneously immortalized cell line DT Created: 04-04-12; Last updated: 24-05-19; Version: 16

Sex

DT Created: 04-04-12; Last updated: 24-05-19; Version: 16

Synonyms

UMNSAH-DF-1, UMNSAH-DF 1, UMNSAH-DF1, UMNSAH/DF#1, DF-1, DF1, Douglas Foster-1 DT Created: 04-04-12, Last updated: 24-05-19, Version: 16

Vendor

BCRJ

Cat Num

0307

Cross References

BTO; BTO:0005956 CLO; CLO_0009484 MCCL; MCC:0000475 ATCC; CRL-12203 BCRJ; 0307 CCLV; CCLV-RIE 1029 CCRID; 3131C0001000400023 GEO; GSE29257 IZSLER; BS CL 197 KCB; KCB 2012111YJ Wikidata; Q54991087 DT Created: 04-04-12; Last updated: 24-05-19; Version: 16

Hierarchy

DT Created: 04-04-12; Last updated: 24-05-19; Version: 16

Originate from Same Individual

DT Created: 04-04-12; Last updated: 24-05-19; Version: 16

Publications that use this research resource

Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors.

  • Blanco-Melo D
  • Elife
  • 2017 Apr 11

Literature context:


Abstract:

Endogenous retroviral sequences provide a molecular fossil record of ancient infections whose analysis might illuminate mechanisms of viral extinction. A close relative of gammaretroviruses, HERV-T, circulated in primates for ~25 million years (MY) before apparent extinction within the past ~8 MY. Construction of a near-complete catalog of HERV-T fossils in primate genomes allowed us to estimate a ~32 MY old ancestral sequence and reconstruct a functional envelope protein (ancHTenv) that could support infection of a pseudotyped modern gammaretrovirus. Using ancHTenv, we identify monocarboxylate transporter-1 (MCT-1) as a receptor used by HERV-T for attachment and infection. A single HERV-T provirus in hominid genomes includes an env gene (hsaHTenv) that has been uniquely preserved. This apparently exapted HERV-T env could not support virion infection but could block ancHTenv mediated infection, by causing MCT-1 depletion from cell surfaces. Thus, hsaHTenv may have contributed to HERV-T extinction, and could also potentially regulate cellular metabolism.