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Rat2

RRID:CVCL_0513

Organism

Rattus norvegicus

Comments

Breed/subspecies: Fischer 344. DT Created: 04-04-12; Last updated: 13-11-18; Version: 13

Proper Citation

ECACC Cat# 94050409, RRID:CVCL_0513

Category

Spontaneously immortalized cell line DT Created: 04-04-12; Last updated: 13-11-18; Version: 13

Sex

DT Created: 04-04-12; Last updated: 13-11-18; Version: 13

Synonyms

RAT2, Rat-2, RAT-2, Rat 2 DT Created: 04-04-12, Last updated: 13-11-18, Version: 13

Vendor

ECACC

Cat Num

94050409

Cross References

BTO; BTO:0002874 CLO; CLO_0008749 CLO; CLO_0008750 MCCL; MCC:0000412 CLDB; cl4104 CLDB; cl4105 CLDB; cl4106 ATCC; CRL-1764 BCRC; 60322 ECACC; 94050409 IZSLER; BS CL 231 JCRB; IFO50282 Lonza; 379 TOKU-E; 2974 Wikidata; Q54949241 DT Created: 04-04-12; Last updated: 13-11-18; Version: 13

Hierarchy

DT Created: 04-04-12; Last updated: 13-11-18; Version: 13

Originate from Same Individual

DT Created: 04-04-12; Last updated: 13-11-18; Version: 13

Publications that use this research resource

Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors.

  • Blanco-Melo D
  • Elife
  • 2017 Apr 11

Literature context:


Abstract:

Endogenous retroviral sequences provide a molecular fossil record of ancient infections whose analysis might illuminate mechanisms of viral extinction. A close relative of gammaretroviruses, HERV-T, circulated in primates for ~25 million years (MY) before apparent extinction within the past ~8 MY. Construction of a near-complete catalog of HERV-T fossils in primate genomes allowed us to estimate a ~32 MY old ancestral sequence and reconstruct a functional envelope protein (ancHTenv) that could support infection of a pseudotyped modern gammaretrovirus. Using ancHTenv, we identify monocarboxylate transporter-1 (MCT-1) as a receptor used by HERV-T for attachment and infection. A single HERV-T provirus in hominid genomes includes an env gene (hsaHTenv) that has been uniquely preserved. This apparently exapted HERV-T env could not support virion infection but could block ancHTenv mediated infection, by causing MCT-1 depletion from cell surfaces. Thus, hsaHTenv may have contributed to HERV-T extinction, and could also potentially regulate cellular metabolism.