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CV-1

RRID:CVCL_0229

Organism

Chlorocebus aethiops

Comments

Group: Non-human primate cell line. Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982). Discontinued: ATCC; CRL-6305. DT Created: 04-04-12; Last updated: 07-09-18; Version: 18

Proper Citation

IZSLER Cat# BS CL 23, RRID:CVCL_0229

Category

Finite cell line DT Created: 04-04-12; Last updated: 07-09-18; Version: 18

Sex

DT Created: 04-04-12; Last updated: 07-09-18; Version: 18

Synonyms

Cv-1, CV 1, CV-1.K, CV1 DT Created: 04-04-12, Last updated: 07-09-18, Version: 18

Vendor

IZSLER

Cat Num

BS CL 23

Cross References

BTO; BTO:0000318 CLO; CLO_0002640 CLO; CLO_0050506 MCCL; MCC:0000117 CLDB; cl928 CLDB; cl929 CLDB; cl931 CLDB; cl932 CLDB; cl933 ATCC; CCL-70 ATCC; CRL-6305 BCRC; 60065 CCRID; 3111C0001CCC000064 CCRID; 3111C0002000000020 CCRID; 3131C0001000400011 ChEMBL-Cells; CHEMBL3308033 ChEMBL-Targets; CHEMBL613507 CLS; 605471/p715_CV-1 ECACC; 87032605 IZSLER; BS CL 23 JCRB; JCRB9049 KCLB; 10070 Lonza; 255 RCB; RCB0160 TKG; TKG 0327 TOKU-E; 1008 Wikidata; Q54814868 DT Created: 04-04-12; Last updated: 07-09-18; Version: 18

Hierarchy

DT Created: 04-04-12; Last updated: 07-09-18; Version: 18

Originate from Same Individual

DT Created: 04-04-12; Last updated: 07-09-18; Version: 18

Publications that use this research resource

Co-option of an endogenous retrovirus envelope for host defense in hominid ancestors.

  • Blanco-Melo D
  • Elife
  • 2017 Apr 11

Literature context:


Abstract:

Endogenous retroviral sequences provide a molecular fossil record of ancient infections whose analysis might illuminate mechanisms of viral extinction. A close relative of gammaretroviruses, HERV-T, circulated in primates for ~25 million years (MY) before apparent extinction within the past ~8 MY. Construction of a near-complete catalog of HERV-T fossils in primate genomes allowed us to estimate a ~32 MY old ancestral sequence and reconstruct a functional envelope protein (ancHTenv) that could support infection of a pseudotyped modern gammaretrovirus. Using ancHTenv, we identify monocarboxylate transporter-1 (MCT-1) as a receptor used by HERV-T for attachment and infection. A single HERV-T provirus in hominid genomes includes an env gene (hsaHTenv) that has been uniquely preserved. This apparently exapted HERV-T env could not support virion infection but could block ancHTenv mediated infection, by causing MCT-1 depletion from cell surfaces. Thus, hsaHTenv may have contributed to HERV-T extinction, and could also potentially regulate cellular metabolism.

EMC1-dependent stabilization drives membrane penetration of a partially destabilized non-enveloped virus.

  • Bagchi P
  • Elife
  • 2016 Dec 24

Literature context:


Abstract:

Destabilization of a non-enveloped virus generates a membrane transport-competent viral particle. Here we probe polyomavirus SV40 endoplasmic reticulum (ER)-to-cytosol membrane transport, a decisive infection step where destabilization initiates this non-enveloped virus for membrane penetration. We find that a member of the ER membrane protein complex (EMC) called EMC1 promotes SV40 ER membrane transport and infection. Surprisingly, EMC1 does so by using its predicted transmembrane residue D961 to bind to and stabilize the membrane-embedded partially destabilized SV40, thereby preventing premature viral disassembly. EMC1-dependent stabilization enables SV40 to engage a cytosolic extraction complex that ejects the virus into the cytosol. Thus EMC1 acts as a molecular chaperone, bracing the destabilized SV40 in a transport-competent state. Our findings reveal the novel principle that coordinated destabilization-stabilization drives membrane transport of a non-enveloped virus.

Funding information:
  • Intramural NIH HHS - R24RR03232601(United States)