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COS-1

RRID:CVCL_0223

Organism

Chlorocebus aethiops

Comments

Group: Non-human primate cell line. Doubling time: ~48 hours (DSMZ). Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) [pSV6-1].

Proper Citation

ECACC Cat# 88031701, RRID:CVCL_0223

Reference

PMID:6260373

Category

Transformed cell line

Sex

Male

Synonyms

Cos-1, COS1, Cos1, CV-1 in Origin Simian-1

Vendor

ECACC

Cat Num

88031701

Cross References

BTO; BTO:0001538 BTO; BTO:0004055 CLO; CLO_0002596 CLO; CLO_0050514 MCCL; MCC:0000111 CLDB; cl886 CLDB; cl887 CLDB; cl888 CLDB; cl889 CLDB; cl7122 AddexBio; T0014001/34 ATCC; CRL-1650 BCRC; 60002 BCRJ; 0070 CCRID; 3111C0001CCC000157 CCRID; 3131C0001000400001 CCRID; 3153C0001000000088 ChEMBL-Cells; CHEMBL3308351 ChEMBL-Targets; CHEMBL614563 DSMZ; ACC-63 ECACC; 88031701 ICLC; ATL01002 IZSLER; BS CL 95 JCRB; JCRB9082 KCB; KCB 93018YJ KCLB; 21650 Lonza; 722 MeSH; D019556 NCBI_Iran; C518 RCB; RCB0143 TOKU-E; 992 Wikidata; Q27556079

Hierarchy

CVCL_0229 ! CV-1

Publications that use this research resource

Ciliary and rhabdomeric photoreceptor-cell circuits form a spectral depth gauge in marine zooplankton.

  • Verasztó C
  • Elife
  • 2018 May 29

Literature context: (Cercopithecus aethiops) COS1 RRID:CVCL_0223 ATCC® CRL1650™


Abstract:

Ciliary and rhabdomeric photoreceptor cells represent two main lines of photoreceptor-cell evolution in animals. The two cell types coexist in some animals, however how these cells functionally integrate is unknown. We used connectomics to map synaptic paths between ciliary and rhabdomeric photoreceptors in the planktonic larva of the annelid Platynereis and found that ciliary photoreceptors are presynaptic to the rhabdomeric circuit. The behaviors mediated by the ciliary and rhabdomeric cells also interact hierarchically. The ciliary photoreceptors are UV-sensitive and mediate downward swimming in non-directional UV light, a behavior absent in ciliary-opsin knockout larvae. UV avoidance overrides positive phototaxis mediated by the rhabdomeric eyes such that vertical swimming direction is determined by the ratio of blue/UV light. Since this ratio increases with depth, Platynereis larvae may use it as a depth gauge during vertical migration. Our results revealed a functional integration of ciliary and rhabdomeric photoreceptor cells in a zooplankton larva.

Funding information:
  • Austrian Science Fund - P28970()
  • Deutsche Forschungsgemeinschaft - JE 777/3-1()
  • European Research Council - 337011()
  • FP7 Ideas: European Research Council - Grant Agreement 33701()
  • Max-Planck-Gesellschaft - Open-access funding()
  • NCI NIH HHS - CA129825(United States)
  • NEI NIH HHS - R01 EY016400()

As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid.

  • Pavlova NN
  • Cell Metab.
  • 2018 Feb 6

Literature context: en Monkey: Cos-1 ATCC CRL-1650; RRID:CVCL_0223 Human: HeLa ATCC CCL-2; CVCL_00


Abstract:

When mammalian cells are deprived of glutamine, exogenous asparagine rescues cell survival and growth. Here we report that this rescue results from use of asparagine in protein synthesis. All mammalian cell lines tested lacked cytosolic asparaginase activity and could not utilize asparagine to produce other amino acids or biosynthetic intermediates. Instead, most glutamine-deprived cell lines are capable of sufficient glutamine synthesis to maintain essential amino acid uptake and production of glutamine-dependent biosynthetic precursors, with the exception of asparagine. While experimental introduction of cytosolic asparaginase could enhance the synthesis of glutamine and increase tricarboxylic acid cycle anaplerosis and the synthesis of nucleotide precursors, cytosolic asparaginase suppressed the growth and survival of cells in glutamine-depleted medium in vitro and severely compromised the in vivo growth of tumor xenografts. These results suggest that the lack of asparaginase activity represents an evolutionary adaptation to allow mammalian cells to survive pathophysiologic variations in extracellular glutamine.

Funding information:
  • NCI NIH HHS - P30 CA008748()
  • NIAID NIH HHS - R21 AI091457(United States)