URL: https://web.expasy.org/cellosaurus/CVCL_0006
Proper Citation: (RRID:CVCL_0006)
Description: Cell line THP-1 is a Cancer cell line with a species of origin Homo sapiens (Human)
Sex: Male
Disease: Childhood acute monocytic leukemia
Defining Citation: PMID:1571549, PMID:1915666, PMID:2633408, PMID:2985879, PMID:3159941, PMID:3874327, PMID:6091813, PMID:6949641, PMID:6970727, PMID:8558913, PMID:9290701, PMID:9379676, PMID:9510473, PMID:9738977, PMID:10223614, PMID:10739008, PMID:11066077, PMID:11226526, PMID:11414198, PMID:11416159, PMID:12068308, PMID:14504097, PMID:14671638, PMID:15843827, PMID:16311011, PMID:16337770, PMID:16408098, PMID:19220422, PMID:19377474, PMID:20215515, PMID:22460905, PMID:22481983, PMID:22645513, PMID:22674354, PMID:23097634, PMID:23955599, PMID:24368162, PMID:25130606, PMID:25485619, PMID:25877200, PMID:25984343, PMID:26421875, PMID:26589293, PMID:27397505, PMID:28109323, PMID:28196595, PMID:28404994, PMID:29169185, PMID:29787063, PMID:29901211, PMID:30285677, PMID:30629668, PMID:30894373, PMID:31068700, PMID:31160637, PMID:31978347, PMID:32387766, PMID:33389257, PMID:35373342, PMID:35839778
Comments: Caution: NRAS mutation indicated incorrectly as being p.Gly12Ser in PubMed=9379676.., Anecdotal: Have been flown in space on Cosmos-2044 to study the inhibition of phorbol ester-induced cell activation in microgravity (PubMed=1915666)., Omics: Transcriptome analysis by RNAseq., Omics: Transcriptome analysis by microarray., Omics: SNP array analysis., Omics: shRNA library screening., Omics: Protein expression by reverse-phase protein arrays., Omics: HLA class I peptidome analysis by proteomics., Omics: Glycoproteome analysis by proteomics., Omics: DNA methylation analysis., Omics: Deep quantitative proteome analysis., Omics: Deep promoter analysis., Omics: Deep exome analysis., Omics: Deep antibody staining analysis., Virology: Not susceptible to infection by SARS coronavirus 2 (SARS-CoV-2) (COVID-19) (PubMed=33389257)., Characteristics: Can differentiate from monocytes into macrophage-like cells upon stimulation with PMA., Biotechnology: Used in the human Cell Line Activation Test (h-CLAT), an in vitro skin sensitization test (PubMed=16311011; PubMed=16337770; PubMed=29901211)., Population: Japanese., Part of: Tumor Immunology Bank (TIB) collection from Salk (transferred to ATCC in 1981)., Part of: RAS genetic alteration cell panel (ATCC TCP-1031)., Part of: MD Anderson Cell Lines Project., Part of: LL-100 blood cancer cell line panel., Part of: COSMIC cell lines project., Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE)., Group: Space-flown cell line (cellonaut).
Category: Cancer cell line
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Source: Cellosaurus
