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Anti-Brn-3a antibody

RRID:AB_92154

Antibody ID

AB_92154

Target Antigen

Brn-3a h, m

Proper Citation

(Millipore Cat# AB5945, RRID:AB_92154)

Clonality

polyclonal antibody

Comments

seller recommendations: IC, IH, WB; Immunocytochemistry; Western Blot; Immunohistochemistry

Host Organism

rabbit

Vendor

Millipore

Cat Num

AB5945

Publications that use this research resource

A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice.

  • Chew KS
  • Elife
  • 2017 Jun 15

Literature context: #AB5945, RRID:AB_92154) (1:250),


Abstract:

The visual system consists of two major subsystems, image-forming circuits that drive conscious vision and non-image-forming circuits for behaviors such as circadian photoentrainment. While historically considered non-overlapping, recent evidence has uncovered crosstalk between these subsystems. Here, we investigated shared developmental mechanisms. We revealed an unprecedented role for light in the maturation of the circadian clock and discovered that intrinsically photosensitive retinal ganglion cells (ipRGCs) are critical for this refinement process. In addition, ipRGCs regulate retinal waves independent of light, and developmental ablation of a subset of ipRGCs disrupts eye-specific segregation of retinogeniculate projections. Specifically, a subset of ipRGCs, comprising ~200 cells and which project intraretinally and to circadian centers in the brain, are sufficient to mediate both of these developmental processes. Thus, this subset of ipRGCs constitute a shared node in the neural networks that mediate light-dependent maturation of the circadian clock and light-independent refinement of retinogeniculate projections.

Funding information:
  • NEI NIH HHS - F32 EY020108()
  • NEI NIH HHS - R01 EY017137()
  • NEI NIH HHS - R01 EY019053()
  • NEI NIH HHS - R15 EY026255()
  • NHLBI NIH HHS - R01 HL089742()
  • NIDCD NIH HHS - R01 DC007395()
  • NIGMS NIH HHS - R01 GM076430()
  • NIGMS NIH HHS - R01 GM104991()