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ICAM1 antibody [EP1442Y]

RRID:AB_870702

Antibody ID

AB_870702

Target Antigen

ICAM1 antibody [EP1442Y] human

Proper Citation

(Abcam Cat# ab53013, RRID:AB_870702)

Clonality

monoclonal antibody

Reference

PMID:29578406

Comments

validation status unknown, seller recommendations provided in 2012: Immunofluorescence; Immunohistochemistry; Immunocytochemistry; Western Blot; Immunohistochemistry - fixed; ICC/IF, IHC-P, WB

Host Organism

rabbit

Vendor

Abcam

Cat Num

ab53013

Publications that use this research resource

Neurovascular sequestration in paediatric P. falciparum malaria is visible clinically in the retina.

  • Barrera V
  • Elife
  • 2018 Mar 26

Literature context:


Abstract:

Retinal vessel changes and retinal whitening, distinctive features of malarial retinopathy, can be directly observed during routine eye examination in children with P. falciparum cerebral malaria. We investigated their clinical significance and underlying mechanisms through linked clinical, clinicopathological and image analysis studies. Orange vessels and severe foveal whitening (clinical examination, n = 817, OR, 95% CI: 2.90, 1.96-4.30; 3.4, 1.8-6.3, both p<0.001), and arteriolar involvement by intravascular filling defects (angiographic image analysis, n = 260, 2.81, 1.17-6.72, p<0.02) were strongly associated with death. Orange vessels had dense sequestration of late stage parasitised red cells (histopathology, n = 29; sensitivity 0.97, specificity 0.89) involving 360° of the lumen circumference, with altered protein expression in blood-retinal barrier cells and marked loss/disruption of pericytes. Retinal whitening was topographically associated with tissue response to hypoxia. Severe neurovascular sequestration is visible at the bedside, and is a marker of severe disease useful for diagnosis and management.

Funding information:
  • Medical Research Council - 069962/Z/02/Z(United Kingdom)
  • NIH Clinical Center - #5R01AI034969-11()
  • Wellcome - #074125()
  • Wellcome - #092668/Z/10/Z()