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Mouse Anti-Drosophila Yan Drosophila protein Antibody, Unconjugated

RRID:AB_531807

Antibody ID

AB_531807

Target Antigen

Mouse Drosophila Yan Drosophila protein drosophila/arthropod, drosophila

Proper Citation

(DSHB Cat# anti-Yan 8B12H9, RRID:AB_531807)

Clonality

unknown

Comments

manufacturer recommendations: IgG1 Western Blot; Immunoblotting

Host Organism

mouse

Vendor

DSHB Go To Vendor

Cat Num

anti-Yan 8B12H9

Publications that use this research resource

Hippo Reprograms the Transcriptional Response to Ras Signaling.

  • Pascual J
  • Dev. Cell
  • 2017 Sep 25

Literature context:


Abstract:

Hyperactivating mutations in Ras signaling are hallmarks of carcinomas. Ras signaling mediates cell fate decisions as well as proliferation during development. It is not known what dictates whether Ras signaling drives differentiation versus proliferation. Here we show that the Hippo pathway is critical for this decision. Loss of Hippo switches Ras activation from promoting cellular differentiation to aggressive cellular proliferation. Transcriptome analysis combined with genetic tests show that this excessive proliferation depends on the synergistic induction of Ras target genes. Using ChIP-nexus, we find that Hippo signaling keeps Ras targets in check by directly regulating the expression of two key downstream transcription factors of Ras signaling: the ETS-domain transcription factor Pointed and the repressor Capicua. Our results highlight how independent signaling pathways can impinge on each other at the level of transcription factors, thereby providing a safety mechanism to keep proliferation in check under normal developmental conditions.