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a-CGRP (human) - Undiluted Antiserum for Immunohistochemistry, Host: Rabbit antibody


Antibody ID


Target Antigen

a-CGRP (human) - Undiluted Antiserum for Immunohistochemistry Host: Rabbit human

Proper Citation

(Peninsula Laboratories Cat# T-4239.0050, RRID:AB_518150)




Discontinued: 2014; manufacturer recommendations: Immunohistochemistry; Immunohistochemistry

Host Organism



Peninsula Laboratories

Cat Num


Publications that use this research resource

Leaky Gate Model: Intensity-Dependent Coding of Pain and Itch in the Spinal Cord.

  • Sun S
  • Neuron
  • 2017 Feb 22

Literature context: # T-4239; RRID:AB_518150 rabbit ant


Coding of itch versus pain has been heatedly debated for decades. However, the current coding theories (labeled line, intensity, and selectivity theory) cannot accommodate all experimental observations. Here we identified a subset of spinal interneurons, labeled by gastrin-releasing peptide (Grp), that receive direct synaptic input from both pain and itch primary sensory neurons. When activated, these Grp+ neurons generated rarely seen, simultaneous robust pain and itch responses that were intensity dependent. Accordingly, we propose a "leaky gate" model in which Grp+ neurons transmit both itch and weak pain signals; however, upon strong painful stimuli, the recruitment of endogenous opioids works to close this gate, reducing overwhelming pain generated by parallel pathways. Consistent with our model, loss of these Grp+ neurons increased pain responses while itch was decreased. Our new model serves as an example of non-monotonic coding in the spinal cord and better explains observations in human psychophysical studies.

Funding information:
  • NEI NIH HHS - R01 EY024704()
  • NIAID NIH HHS - R01 AI125743()
  • NIDCR NIH HHS - R01 DE022750()
  • NINDS NIH HHS - R01 NS054791()
  • NINDS NIH HHS - R01 NS070814()