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Pacific Blue™ anti-human CD8a antibody

RRID:AB_493111

Antibody ID

AB_493111

Target Antigen

CD8a See NCBI gene human, cross-reactivity: chimpanzee, baboon, cynomolgus, rhesus, pigtailed macaque, sooty mangabey

Proper Citation

(BioLegend Cat# 301026, RRID:AB_493111)

Clonality

monoclonal antibody

Reference

PMID:29331015

Comments

Applications: FC

Clone ID

Clone RPA-T8

Host Organism

mouse

Vendor

BioLegend Go To Vendor

Cat Num

301026

Publications that use this research resource

Detection of human disease conditions by single-cell morpho-rheological phenotyping of blood.

  • Toepfner N
  • Elife
  • 2018 Jan 13

Literature context:


Abstract:

Blood is arguably the most important bodily fluid and its analysis provides crucial health status information. A first routine measure to narrow down diagnosis in clinical practice is the differential blood count, determining the frequency of all major blood cells. What is lacking to advance initial blood diagnostics is an unbiased and quick functional assessment of blood that can narrow down the diagnosis and generate specific hypotheses. To address this need, we introduce the continuous, cell-by-cell morpho-rheological (MORE) analysis of diluted whole blood, without labeling, enrichment or separation, at rates of 1000 cells/sec. In a drop of blood we can identify all major blood cells and characterize their pathological changes in several disease conditions in vitro and in patient samples. This approach takes previous results of mechanical studies on specifically isolated blood cells to the level of application directly in blood and adds a functional dimension to conventional blood analysis.

Funding information:
  • Alexander von Humboldt-Stiftung - Alexander von Humboldt Professorship()
  • Bundesministerium für Bildung und Forschung - German Center for Diabetes Research (DZD e.V.)()
  • Deutsche Forschungsgemeinschaft - TRR83 and SFB655()
  • European Research Council - 282060()
  • GlaxoSmithKline - Non-commercial grant()
  • National Institute for Health Research - Cambridge Biomedical Research Centre()
  • NEI NIH HHS - R01 EY021862(United States)
  • Sächsisches Staatsministerium für Wissenschaft und Kunst - TG70 AZ 4-7531.60/29/45()
  • Seventh Framework Programme - ERC Starting Grant #282060()
  • Seventh Framework Programme - ITN()
  • Sonnenstrahl e.V. Dresden - Non-commercial grant()
  • Technische Universität Dresden - Support the Best Program()
  • Tour der Hoffnung - Non-commercial grant()
  • Zentrum für Regenerative Therapien Dresden - Seed grant FZ 111()