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Mouse Podocalyxin Affinity Purified Polyclonal Ab antibody

RRID:AB_354858

Antibody ID

AB_354858

Target Antigen

Mouse Podocalyxin Affinity Purified Ab mouse

Proper Citation

(R and D Systems Cat# AF1556, RRID:AB_354858)

Clonality

polyclonal antibody

Comments

vendor recommendations: IgG Immunohistochemistry; Immunocytochemistry; Western Blot; Flow Cytometry; Flow Cytometry, Immunohistochemistry, Western Blot

Host Organism

goat

Vendor

R and D Systems

Cat Num

AF1556

Publications that use this research resource

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury.

  • Dias DO
  • Cell
  • 2018 Mar 22

Literature context: ms AF1556; RRID:AB_354858 Rabbit anti S100 DAKO Z0311; RR


Abstract:

CNS injury often severs axons. Scar tissue that forms locally at the lesion site is thought to block axonal regeneration, resulting in permanent functional deficits. We report that inhibiting the generation of progeny by a subclass of pericytes led to decreased fibrosis and extracellular matrix deposition after spinal cord injury in mice. Regeneration of raphespinal and corticospinal tract axons was enhanced and sensorimotor function recovery improved following spinal cord injury in animals with attenuated pericyte-derived scarring. Using optogenetic stimulation, we demonstrate that regenerated corticospinal tract axons integrated into the local spinal cord circuitry below the lesion site. The number of regenerated axons correlated with improved sensorimotor function recovery. In conclusion, attenuation of pericyte-derived fibrosis represents a promising therapeutic approach to facilitate recovery following CNS injury.

Funding information:
  • Intramural NIH HHS - Z01 DE000698-10(United States)