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APC anti-mouse I-A/I-E antibody

RRID:AB_313329

Antibody ID

AB_313329

Target Antigen

I-A/I-E mouse

Proper Citation

(BioLegend Cat# 107614, RRID:AB_313329)

Clonality

monoclonal antibody

Comments

Applications: FC

Clone ID

Clone M5/114.15.2

Host Organism

rat

Vendor

BioLegend Go To Vendor

Cat Num

107614

Publications that use this research resource

Brain micro-inflammation at specific vessels dysregulates organ-homeostasis via the activation of a new neural circuit.

  • Arima Y
  • Elife
  • 2017 Aug 15

Literature context:


Abstract:

Impact of stress on diseases including gastrointestinal failure is well-known, but molecular mechanism is not understood. Here we show underlying molecular mechanism using EAE mice. Under stress conditions, EAE caused severe gastrointestinal failure with high-mortality. Mechanistically, autoreactive-pathogenic CD4+ T cells accumulated at specific vessels of boundary area of third-ventricle, thalamus, and dentate-gyrus to establish brain micro-inflammation via stress-gateway reflex. Importantly, induction of brain micro-inflammation at specific vessels by cytokine injection was sufficient to establish fatal gastrointestinal failure. Resulting micro-inflammation activated new neural pathway including neurons in paraventricular-nucleus, dorsomedial-nucleus-of-hypothalamus, and also vagal neurons to cause fatal gastrointestinal failure. Suppression of the brain micro-inflammation or blockage of these neural pathways inhibited the gastrointestinal failure. These results demonstrate direct link between brain micro-inflammation and fatal gastrointestinal disease via establishment of a new neural pathway under stress. They further suggest that brain micro-inflammation around specific vessels could be switch to activate new neural pathway(s) to regulate organ homeostasis.