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PE anti-mouse CD8a antibody

RRID:AB_312747

Antibody ID

AB_312747

Target Antigen

CD8a See NCBI gene mouse

Proper Citation

(BioLegend Cat# 100708, RRID:AB_312747)

Clonality

monoclonal antibody

Comments

Applications: FC

Clone ID

Clone 53-6.7

Host Organism

rat

Vendor

BioLegend Go To Vendor

Cat Num

100708

Publications that use this research resource

KLRG1+ Effector CD8+ T Cells Lose KLRG1, Differentiate into All Memory T Cell Lineages, and Convey Enhanced Protective Immunity.

  • Herndler-Brandstetter D
  • Immunity
  • 2018 Apr 17

Literature context: Legend Cat#100708; RRID:AB_312747 Anti-mouse CD8α (53-6.7) PE-Cy7


Abstract:

Protective immunity against pathogens depends on the efficient generation of functionally diverse effector and memory T lymphocytes. However, whether plasticity during effector-to-memory CD8+ T cell differentiation affects memory lineage specification and functional versatility remains unclear. Using genetic fate mapping analysis of highly cytotoxic KLRG1+ effector CD8+ T cells, we demonstrated that KLRG1+ cells receiving intermediate amounts of activating and inflammatory signals downregulated KLRG1 during the contraction phase in a Bach2-dependent manner and differentiated into all memory T cell linages, including CX3CR1int peripheral memory cells and tissue-resident memory cells. "ExKLRG1" memory cells retained high cytotoxic and proliferative capacity distinct from other populations, which contributed to effective anti-influenza and anti-tumor immunity. Our work demonstrates that developmental plasticity of KLRG1+ effector CD8+ T cells is important in promoting functionally versatile memory cells and long-term protective immunity.

Funding information:
  • NIAID NIH HHS - T32AI055434(United States)