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HJ9.3 antibody

RRID:AB_2721235

Antibody ID

AB_2721235

Target Antigen

tau human, mouse

Proper Citation

(D. Holtzman at Washington University School of Medicine; Missouri; USA Cat# HJ9.3, RRID:AB_2721235)

Clonality

monoclonal antibody

Comments

Yanamandra et al., 2013 "HJ9.3 and HJ9.4 mouse monoclonal antibodies were raised by immunizing tau knockout mice (The Jackson laboratory) against mouse tau and HJ8.5 and HJ8.7 monoclonal antibodies were raised by immunizing tau knockout mice against human tau."

Host Organism

mouse

Vendor

D. Holtzman at Washington University School of Medicine; Missouri; USA

Cat Num

HJ9.3

Publications that use this research resource

Tau Kinetics in Neurons and the Human Central Nervous System.

  • Sato C
  • Neuron
  • 2018 Mar 21

Literature context:


Abstract:

We developed stable isotope labeling and mass spectrometry approaches to measure the kinetics of multiple isoforms and fragments of tau in the human central nervous system (CNS) and in human induced pluripotent stem cell (iPSC)-derived neurons. Newly synthesized tau is truncated and released from human neurons in 3 days. Although most tau proteins have similar turnover, 4R tau isoforms and phosphorylated forms of tau exhibit faster turnover rates, suggesting unique processing of these forms that may have independent biological activities. The half-life of tau in control human iPSC-derived neurons is 6.74 ± 0.45 days and in human CNS is 23 ± 6.4 days. In cognitively normal and Alzheimer's disease participants, the production rate of tau positively correlates with the amount of amyloid plaques, indicating a biological link between amyloid plaques and tau physiology.

Funding information:
  • Wellcome Trust - 083167/Z07/Z(United Kingdom)