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Anti-NeuN antibody

RRID:AB_2619988

Antibody ID

AB_2619988

Target Antigen

NeuN rat, mouse

Vendor

Synaptic Systems Go To Vendor

Cat Num

266 004

Proper Citation

(Synaptic Systems Cat# 266 004, RRID:AB_2619988)

Clonality

polyclonal antibody

Host Organism

guinea pig

Comments

Applications: ICC,IHC,IHC-P

Publications that use this research resource

Early tissue damage and microstructural reorganization predict disease severity in experimental epilepsy.

  • Janz P
  • Elife
  • 2017 Jul 26

Literature context: ): Guinea pig anti-NeuN (1:500; RRID:AB_2619988, Synaptic Systems, Göttingen, G


Abstract:

Mesial temporal lobe epilepsy (mTLE) is the most common focal epilepsy in adults and is often refractory to medication. So far, resection of the epileptogenic focus represents the only curative therapy. It is unknown whether pathological processes preceding epilepsy onset are indicators of later disease severity. Using longitudinal multi-modal MRI, we monitored hippocampal injury and tissue reorganization during epileptogenesis in a mouse mTLE model. The prognostic value of MRI biomarkers was assessed by retrospective correlations with pathological hallmarks Here, we show for the first time that the extent of early hippocampal neurodegeneration and progressive microstructural changes in the dentate gyrus translate to the severity of hippocampal sclerosis and seizure burden in chronic epilepsy. Moreover, we demonstrate that structural MRI biomarkers reflect the extent of sclerosis in human hippocampi. Our findings may allow an early prognosis of disease severity in mTLE before its first clinical manifestations, thus expanding the therapeutic window.