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pMad, PS1 antibody

RRID:AB_2617125

Antibody ID

AB_2617125

Target Antigen

phosphorylated C-tail of Smad1

Proper Citation

(Carl-Henrik Heldin Göteborg University, Sweden Cat# pMad, RRID:AB_2617125)

Clonality

unknown

Host Organism

rabbit

Vendor

Carl-Henrik Heldin Göteborg University, Sweden

Cat Num

pMad

Publications that use this research resource

The L45 loop in type I receptors for TGF-beta family members is a critical determinant in specifying Smad isoform activation.

  • Persson U
  • FEBS Lett.
  • 1998 Aug 28

Literature context:


Abstract:

Transforming growth factor-beta (TGF-beta) and bone morphogenetic proteins (BMPs) signal via distinct type I and type II receptors and Smad proteins. A nine amino acid sequence between kinase subdomains IV and V in type I receptors, termed the L45 loop, has been shown to be important in conferring signalling specificity. We examined the responses of a mutant TGF-beta type I receptor (TbetaR-I) and a mutant BMPR-IB, in which the L45 regions of these two receptors were exchanged. Swapping the four amino acid residues that are different in BMPR-IB for those in TbetaR-I, and vice versa, switched their type I receptor-restricted Smad activation and specificity in transcriptional responses. These studies identify the L45 loop regions in type I receptors as critical determinants in specifying Smad isoform activation.

Funding information:
  • NHGRI NIH HHS - R01 HG004701-01(United States)