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Calbindin (CB-28kD) antibody

RRID:AB_2571569

Antibody ID

AB_2571569

Target Antigen

Calbindin 28kD

Proper Citation

(Frontier Institute Cat# Calbindin-Go, RRID:AB_2571569)

Clonality

polyclonal antibody

Host Organism

goat

Vendor

Frontier Institute Go To Vendor

Cat Num

Calbindin-Go

Publications that use this research resource

Entorhinal-CA3 Dual-Input Control of Spike Timing in the Hippocampus by Theta-Gamma Coupling.

  • Fern├índez-Ruiz A
  • Neuron
  • 2017 Mar 8

Literature context:


Abstract:

Theta-gamma phase coupling and spike timing within theta oscillations are prominent features of the hippocampus and are often related to navigation and memory. However, the mechanisms that give rise to these relationships are not well understood. Using high spatial resolution electrophysiology, we investigated the influence of CA3 and entorhinal inputs on the timing of CA1 neurons. The theta-phase preference and excitatory strength of the afferent CA3 and entorhinal inputs effectively timed the principal neuron activity, as well as regulated distinct CA1 interneuron populations in multiple tasks and behavioral states. Feedback potentiation of distal dendritic inhibition by CA1 place cells attenuated the excitatory entorhinal input at place field entry, coupled with feedback depression of proximal dendritic and perisomatic inhibition, allowing the CA3 input to gain control toward the exit. Thus, upstream inputs interact with local mechanisms to determine theta-phase timing of hippocampal neurons to support memory and spatial navigation.

Funding information:
  • NIMH NIH HHS - R01 MH054671()
  • NIMH NIH HHS - R01 MH107396()
  • NIMH NIH HHS - R01 MH109548()
  • NINDS NIH HHS - R01 NS034994()
  • NINDS NIH HHS - R01 NS074015()
  • NINDS NIH HHS - U01 NS090583()