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defective proventriculus antibody

RRID:AB_2568983

Antibody ID

AB_2568983

Target Antigen

dve d melanogaster

Proper Citation

(Nakagoshi H; Genes Dev. 1998 Cat# dve, RRID:AB_2568983)

Clonality

polyclonal antibody

Comments

Lab generated antibody, submitted by FlyBase FBgn0020307

Vendor

Nakagoshi H; Genes Dev. 1998 Go To Vendor

Cat Num

dve

Publications that use this research resource

Parallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochastic Drosophila retina.

  • Wells BS
  • Elife
  • 2017 Aug 30

Literature context:


Abstract:

Drosophila color vision is achieved by comparing outputs from two types of color-sensitive photoreceptors, R7 and R8. Ommatidia (unit eyes) are classified into two subtypes, known as 'pale' or 'yellow', depending on Rhodopsin expression in R7 and R8. Subtype specification is controlled by a stochastic decision in R7 and instructed to the underlying R8. We find that the Activin receptor Baboon is required in R8 to receive non-redundant signaling from the three Activin ligands, activating the transcription factor dSmad2. Concomitantly, two BMP ligands activate their receptor, Thickveins, and the transcriptional effector, Mad. The Amon TGFβ processing factor appears to regulate components of the TGFβ pathway specifically in pale R7. Mad and dSmad2 cooperate to modulate the Hippo pathway kinase Warts and the growth regulator Melted; two opposing factors of a bi-stable loop regulating R8 Rhodopsin expression. Therefore, TGFβ and growth pathways interact in postmitotic cells to precisely coordinate cell-specific output.

A novel homeobox gene mediates the Dpp signal to establish functional specificity within target cells.

  • Nakagoshi H
  • Genes Dev.
  • 1998 Sep 1

Literature context:


Abstract:

Morphogen gradients of secreted molecules play critical roles in the establishment of the spatial pattern of gene expression. During midgut development in Drosophila, secreted molecules of Decapentaplegic (Dpp) and Wingless (Wg) establish unique transcriptional regulation within target cells to specify the resultant cell types. Here we report the identification of a novel homeobox gene, defective proventriculus (dve), which is required for the midgut specification under the control of Dpp and Wg. In dve mutants, two distinct parts of the midgut, the proventriculus and middle midgut, are abnormally organized. The Wg signal regulates dve expression during proventriculus development. On the other hand, dve is a downstream target of Dpp in the middle midgut and defines the functional specificity of copper cells along with another Dpp target gene, labial. Thus, the dve gene acts under the two distinct extracellular signals at distant parts of the midgut primordia.

Funding information:
  • NIDCR NIH HHS - DE017106(United States)