X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Myocyte enhancer factor 2 antibody

RRID:AB_2568604

Antibody ID

AB_2568604

Target Antigen

Mef2 d melanogaster

Proper Citation

(Lilly B; Science. 1995 Cat# Mef2, RRID:AB_2568604)

Clonality

polyclonal antibody

Comments

Lab generated antibody, submitted by FlyBase FBgn0011656

Vendor

Lilly B; Science. 1995 Go To Vendor

Cat Num

Mef2

Publications that use this research resource

Identification and functional characterization of muscle satellite cells in Drosophila.

  • Chaturvedi D
  • Elife
  • 2017 Oct 26

Literature context:


Abstract:

Work on genetic model systems such as Drosophila and mouse has shown that the fundamental mechanisms of myogenesis are remarkably similar in vertebrates and invertebrates. Strikingly, however, satellite cells, the adult muscle stem cells that are essential for the regeneration of damaged muscles in vertebrates, have not been reported in invertebrates. In this study, we show that lineal descendants of muscle stem cells are present in adult muscle of Drosophila as small, unfused cells observed at the surface and in close proximity to the mature muscle fibers. Normally quiescent, following muscle fiber injury, we show that these cells express Zfh1 and engage in Notch-Delta-dependent proliferative activity and generate lineal descendant populations, which fuse with the injured muscle fiber. In view of strikingly similar morphological and functional features, we consider these novel cells to be the Drosophila equivalent of vertebrate muscle satellite cells.