Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

DYKDDDDK Tag Monoclonal Antibody (L5)


Antibody ID


Target Antigen


Proper Citation

(Thermo Fisher Scientific Cat# MA1-142, RRID:AB_2536846)


monoclonal antibody


Applications: WB (1 µg/mL), ELISA (100 ng/mL)

Clone ID

Clone L5

Host Organism



Thermo Fisher Scientific Go To Vendor

Cat Num


Publications that use this research resource

Npas4 Is a Critical Regulator of Learning-Induced Plasticity at Mossy Fiber-CA3 Synapses during Contextual Memory Formation.

  • Weng FJ
  • Neuron
  • 2018 Mar 7

Literature context:


Synaptic connections between hippocampal mossy fibers (MFs) and CA3 pyramidal neurons are essential for contextual memory encoding, but the molecular mechanisms regulating MF-CA3 synapses during memory formation and the exact nature of this regulation are poorly understood. Here we report that the activity-dependent transcription factor Npas4 selectively regulates the structure and strength of MF-CA3 synapses by restricting the number of their functional synaptic contacts without affecting the other synaptic inputs onto CA3 pyramidal neurons. Using an activity-dependent reporter, we identified CA3 pyramidal cells that were activated by contextual learning and found that MF inputs on these cells were selectively strengthened. Deletion of Npas4 prevented both contextual memory formation and this learning-induced synaptic modification. We further show that Npas4 regulates MF-CA3 synapses by controlling the expression of the polo-like kinase Plk2. Thus, Npas4 is a critical regulator of experience-dependent, structural, and functional plasticity at MF-CA3 synapses during contextual memory formation.

Funding information:
  • FIC NIH HHS - 1R03TW008208(United States)
  • NIDA NIH HHS - R01 DA017392()
  • NIDCD NIH HHS - R01 DC014701()
  • NIMH NIH HHS - R01 MH081935()
  • NIMH NIH HHS - R01 MH091220()
  • NINDS NIH HHS - R21 NS088412()