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Sheep Anti-Mouse Erbb3 / her3 Affinity purified Polyclonal antibody, Unconjugated

RRID:AB_2099728

Antibody ID

AB_2099728

Target Antigen

Mouse ErbB3 / HER3 mouse

Vendor

R and D Systems

Cat Num

AF4518

Proper Citation

(R and D Systems Cat# AF4518, RRID:AB_2099728)

Reference

PMID:28414273

Clonality

polyclonal antibody

Host Organism

sheep

Comments

vendor recommendations: Immunocytochemistry; Immunohistochemistry; Western Blot; Immunohistochemistry, Western Blot

Publications that use this research resource

Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage.

  • Kaucka M
  • Elife
  • 2017 Apr 17

Literature context: N, 1:500, RRID:AB_2099728). For dete


Abstract:

Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.

Funding information:
  • NIBIB NIH HHS - R01 EB014877()