X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Hu protein antibody [16A11]

RRID:AB_2096358

Antibody ID

AB_2096358

Target Antigen

Hu protein human, mouse

Proper Citation

(Abcam Cat# ab14370, RRID:AB_2096358)

Clonality

monoclonal antibody

Reference

PMID:28617242

Comments

validation status unknown, seller recommendations provided in 2012: Immunohistochemistry; Western Blot; Immunohistochemistry-FoFr, Immunohistochemistry-Fr, Western Blot

Clone ID

Clone 16A11

Host Organism

mouse

Vendor

Abcam

Cat Num

ab14370

Publications that use this research resource

A subset of ipRGCs regulates both maturation of the circadian clock and segregation of retinogeniculate projections in mice.

  • Chew KS
  • Elife
  • 2017 Jun 15

Literature context:


Abstract:

The visual system consists of two major subsystems, image-forming circuits that drive conscious vision and non-image-forming circuits for behaviors such as circadian photoentrainment. While historically considered non-overlapping, recent evidence has uncovered crosstalk between these subsystems. Here, we investigated shared developmental mechanisms. We revealed an unprecedented role for light in the maturation of the circadian clock and discovered that intrinsically photosensitive retinal ganglion cells (ipRGCs) are critical for this refinement process. In addition, ipRGCs regulate retinal waves independent of light, and developmental ablation of a subset of ipRGCs disrupts eye-specific segregation of retinogeniculate projections. Specifically, a subset of ipRGCs, comprising ~200 cells and which project intraretinally and to circadian centers in the brain, are sufficient to mediate both of these developmental processes. Thus, this subset of ipRGCs constitute a shared node in the neural networks that mediate light-dependent maturation of the circadian clock and light-independent refinement of retinogeniculate projections.

Funding information:
  • NEI NIH HHS - F32 EY020108()
  • NEI NIH HHS - R01 EY017137()
  • NEI NIH HHS - R01 EY019053()
  • NEI NIH HHS - R15 EY026255()
  • NHLBI NIH HHS - R01 HL089742()
  • NIDCD NIH HHS - R01 DC007395()
  • NIGMS NIH HHS - R01 GM076430()
  • NIGMS NIH HHS - R01 GM104991()