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Rabbit Anti-Olig2 Polyclonal Antibody, Unconjugated

RRID:AB_1640746

Antibody ID

AB_1640746

Target Antigen

Olig2 human, mouse, rat

Proper Citation

(Abcam Cat# ab81093, RRID:AB_1640746)

Clonality

polyclonal antibody

Reference

PMID:25031414

Comments

validation status unknown, seller recommendations provided in 2012: Immunohistochemistry; Western Blot; Immunohistochemistry-Fr, Immunohistochemistry-P, Western Blot

Host Organism

rabbit

Vendor

Abcam

Cat Num

ab81093

Publications that use this research resource

Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes.

  • Bull SJ
  • J. Neurosci.
  • 2014 Jul 16

Literature context:


Abstract:

Paranodal axoglial junctions are critical for maintaining the segregation of axonal domains along myelinated axons; however, the proteins required to organize and maintain this structure are not fully understood. Netrin-1 and its receptor Deleted in Colorectal Cancer (DCC) are proteins enriched at paranodes that are expressed by neurons and oligodendrocytes. To identify the specific function of DCC expressed by oligodendrocytes in vivo, we selectively eliminated DCC from mature myelinating oligodendrocytes using an inducible cre regulated by the proteolipid protein promoter. We demonstrate that DCC deletion results in progressive disruption of the organization of axonal domains, myelin ultrastructure, and myelin protein composition. Conditional DCC knock-out mice develop balance and coordination deficits and exhibit decreased conduction velocity. We conclude that DCC expression by oligodendrocytes is required for the maintenance and stability of myelin in vivo, which is essential for proper signal conduction in the CNS.