X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

Anti-GFP antibody

RRID:AB_11042617

Antibody ID

AB_11042617

Target Antigen

GFP

Proper Citation

(Synaptic Systems Cat# 132 005, RRID:AB_11042617)

Clonality

polyclonal antibody

Comments

Applications: WB,ICC,IHC

Host Organism

guinea pig

Vendor

Synaptic Systems Go To Vendor

Cat Num

132 005

Publications that use this research resource

Embryonic and postnatal neurogenesis produce functionally distinct subclasses of dopaminergic neuron.

  • Galliano E
  • Elife
  • 2018 Apr 20

Literature context:


Abstract:

Most neurogenesis in the mammalian brain is completed embryonically, but in certain areas the production of neurons continues throughout postnatal life. The functional properties of mature postnatally generated neurons often match those of their embryonically produced counterparts. However, we show here that in the olfactory bulb (OB), embryonic and postnatal neurogenesis produce functionally distinct subpopulations of dopaminergic (DA) neurons. We define two subclasses of OB DA neuron by the presence or absence of a key subcellular specialisation: the axon initial segment (AIS). Large AIS-positive axon-bearing DA neurons are exclusively produced during early embryonic stages, leaving small anaxonic AIS-negative cells as the only DA subtype generated via adult neurogenesis. These populations are functionally distinct: large DA cells are more excitable, yet display weaker and - for certain long-latency or inhibitory events - more broadly tuned responses to odorant stimuli. Embryonic and postnatal neurogenesis can therefore generate distinct neuronal subclasses, placing important constraints on the functional roles of adult-born neurons in sensory processing.

Funding information:
  • European Research Council - 725729 FUNCOPLAN()
  • Medical Research Council - MR/M501645/1()
  • National Institutes of Health - DC013329()
  • NHGRI NIH HHS - R01 HG003562(United States)
  • Wellcome - 103044()
  • Wellcome - 88301()