X
Forgot Password

If you have forgotten your password you can enter your email here and get a temporary password sent to your email.

SOX5 antibody

RRID:AB_10859923

Antibody ID

AB_10859923

Target Antigen

SOX5 antibody human

Vendor

Abcam

Cat Num

ab94396

Proper Citation

(Abcam Cat# ab94396, RRID:AB_10859923)

Clonality

polyclonal antibody

Host Organism

rabbit

Comments

seller recommendations: Western Blot; WB

Publications that use this research resource

hPSC Modeling Reveals that Fate Selection of Cortical Deep Projection Neurons Occurs in the Subplate.

  • Ozair MZ
  • Cell Stem Cell
  • 2018 Jul 5

Literature context: l anti-SOX5 Abcam Cat# ab94396; RRID:AB_10859923 Rabbit polyclonal anti-ZNF521 S


Abstract:

Cortical deep projection neurons (DPNs) are implicated in neurodevelopmental disorders. Although recent findings emphasize post-mitotic programs in projection neuron fate selection, the establishment of primate DPN identity during layer formation is not well understood. The subplate lies underneath the developing cortex and is a post-mitotic compartment that is transiently and disproportionately enlarged in primates in the second trimester. The evolutionary significance of subplate expansion, the molecular identity of its neurons, and its contribution to primate corticogenesis remain open questions. By modeling subplate formation with human pluripotent stem cells (hPSCs), we show that all classes of cortical DPNs can be specified from subplate neurons (SPNs). Post-mitotic WNT signaling regulates DPN class selection, and DPNs in the caudal fetal cortex appear to exclusively derive from SPNs. Our findings indicate that SPNs have evolved in primates as an important source of DPNs that contribute to cortical lamination prior to their known role in circuit formation.

Funding information:
  • NIAID NIH HHS - AI020211(United States)

Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage.

  • Kaucka M
  • Elife
  • 2017 Apr 17

Literature context: m, 1:500, RRID:AB_10859923), sheep an


Abstract:

Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.

Funding information:
  • NIBIB NIH HHS - R01 EB014877()