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Anti-SOX9 antibody produced in rabbit

RRID:AB_1080067

Antibody ID

AB_1080067

Target Antigen

SOX9 antibody produced in rabbit human, human

Vendor

Sigma-Aldrich

Cat Num

HPA001758

Proper Citation

(Sigma-Aldrich Cat# HPA001758, RRID:AB_1080067)

Reference

PMID:28414273

Clonality

polyclonal antibody

Host Organism

rabbit

Comments

Vendor recommendations: Immunohistochemistry; Other; indirect immunofluorescence: suitable, protein array: suitable, immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable

Publications that use this research resource

Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage.

  • Kaucka M
  • Elife
  • 2017 Apr 17

Literature context: , 1:1000, RRID:AB_1080067), rabbit a


Abstract:

Cartilaginous structures are at the core of embryo growth and shaping before the bone forms. Here we report a novel principle of vertebrate cartilage growth that is based on introducing transversally-oriented clones into pre-existing cartilage. This mechanism of growth uncouples the lateral expansion of curved cartilaginous sheets from the control of cartilage thickness, a process which might be the evolutionary mechanism underlying adaptations of facial shape. In rod-shaped cartilage structures (Meckel, ribs and skeletal elements in developing limbs), the transverse integration of clonal columns determines the well-defined diameter and resulting rod-like morphology. We were able to alter cartilage shape by experimentally manipulating clonal geometries. Using in silico modeling, we discovered that anisotropic proliferation might explain cartilage bending and groove formation at the macro-scale.

Funding information:
  • NIBIB NIH HHS - R01 EB014877()