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GFAP Polyclonal Antibody

RRID:AB_1074611

Antibody ID

AB_1074611

Target Antigen

GFAP human

Proper Citation

(Thermo Fisher Scientific Cat# PA1-10019, RRID:AB_1074611)

Clonality

polyclonal antibody

Comments

Applications: ICC (1:1000-1:5000), WB (1:5000), IHC (1:1000-1:5000), IF (1:1000-1:5000)

Host Organism

rabbit

Vendor

Thermo Fisher Scientific Go To Vendor

Cat Num

PA1-10019

Publications that use this research resource

Small Networks Encode Decision-Making in Primary Auditory Cortex.

  • Francis NA
  • Neuron
  • 2018 Feb 21

Literature context: Cat# PA1-10019; Lot# QF2036481; RRID:AB_1074611 Mouse monoclonal anti-NeuN EMD


Abstract:

Sensory detection tasks enhance representations of behaviorally meaningful stimuli in primary auditory cortex (A1). However, it remains unclear how A1 encodes decision-making. Neurons in A1 layer 2/3 (L2/3) show heterogeneous stimulus selectivity and complex anatomical connectivity, and receive input from prefrontal cortex. Thus, task-related modulation of activity in A1 L2/3 might differ across subpopulations. To study the neural coding of decision-making, we used two-photon imaging in A1 L2/3 of mice performing a tone-detection task. Neural responses to targets showed attentional gain and encoded behavioral choice. To characterize network representation of behavioral choice, we analyzed functional connectivity using Granger causality, pairwise noise correlations, and neural decoding. During task performance, small groups of four to five neurons became sparsely linked, locally clustered, and rostro-caudally oriented, while noise correlations both increased and decreased. Our results suggest that sensory-based decision-making involves small neural networks driven by the sum of sensory input, attentional gain, and behavioral choice.

Funding information:
  • NCI NIH HHS - U54 CA143874(United States)