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To survive in challenging environments, animals must develop a system to assess food quality and adjust their feeding behavior accordingly. However, the mechanisms that regulate this chronic physiological food evaluation system, which monitors specific nutrients from ingested food and influences food-response behavior, are still not fully understood. Here, we established a low-quality food evaluation assay system and found that heat-killed E. coli (HK-E. coli), a low-sugar food, triggers cellular UPRER and immune response. This encourages animals to avoid low-quality food. The physiological system for evaluating low-quality food depends on the UPRER (IRE-1/XBP-1) - Innate immunity (PMK-1/p38 MAPK) axis, particularly its neuronal function, which subsequently regulates feeding behaviors. Moreover, animals can adapt to a low-quality food environment through sugar supplementation, which inhibits the UPRER -PMK-1 regulated stress response by increasing vitamin C biosynthesis. This study reveals the role of the cellular stress response pathway as physiological food evaluation system for assessing nutritional deficiencies in food, thereby enhancing survival in natural environments.
Pubmed ID: 39235964
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Software package for differential gene expression analysis based on the negative binomial distribution. Used for analyzing RNA-seq data for differential analysis of count data, using shrinkage estimation for dispersions and fold changes to improve stability and interpretability of estimates.
View all literature mentionsManufacturer of mass spectrometry instrumentation used in biomedical and environmental applications. Originally started by scientists from the University of Toronto Institute for Aerospace Studies, it is now part of Danaher Corporation with the SCIEX R&D division still located in Toronto, Canada.
View all literature mentionsCaenorhabditis elegans with name C. elegans wild type (ancestral). from WB.
View all literature mentionsCaenorhabditis elegans with name hif-1(ia4) V. from WB.
View all literature mentionsCaenorhabditis elegans with name zcIs4 V. from WB.
View all literature mentionsCaenorhabditis elegans with name acIs101. from WB.
View all literature mentionsCaenorhabditis elegans with name zcIs13 V. from WB.
View all literature mentionsCaenorhabditis elegans with name agIs17 IV. from WB.
View all literature mentionsCenter that acquires, maintains, and distributes genetic stocks and information about stocks of the small free-living nematode Caenorhabditis elegans for use by investigators initiating or continuing research on this genetic model organism. A searchable strain database, general information about C. elegans, and links to key Web sites of use to scientists, including WormBase, WormAtlas, and WormBook are available.
View all literature mentionsCaenorhabditis elegans with name agIs219 III. from WB.
View all literature mentionsCaenorhabditis elegans with name Caenorhabditis elegans wild isolate. from WB.
View all literature mentionsCaenorhabditis elegans with name pmk-1(km25) IV. from WB.
View all literature mentionsCaenorhabditis elegans with name xbp-1(zc12) III; zcIs4 V. from WB.
View all literature mentionsCaenorhabditis elegans with name kgb-1(km21) IV. from WB.
View all literature mentionsCaenorhabditis elegans with name pmk-1(km25) IV; acEx102. from WB.
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