URL: http://www.wormbase.org/db/get?name=WBStrain00040824
Proper Citation: RRID:WB-STRAIN:WBStrain00040824
Description: Caenorhabditis elegans with name hif-1(ia4) V. from WB.
Species: Caenorhabditis elegans
Synonyms: hif-1(ia4) V.
Notes: Healthy and fertile in standard lab conditions, but unable to adapt to 1% oxygen. When hif-1(+) animals are incubated in1% oxygen, >94% will complete embryogenesis and larval development. In contrast, hif-1(ia4) mutants exhibit 66% embryonic lethality and 9% larval lethality in 1% oxygen. The requirement of hif-1 is alleviated if the oxygen level is increased to 2%. The ia4 mutation is a 1231 bp deletion of the second, third, and fourth exons, which encode much of the helix-loop-helix and PAS domains. Analysis of ESTs suggests that there are at least 4 alternatively spliced hif-1 transcripts. The ia4 deletion introduces a frameshift and a premature stop in the three longest forms.|"Made_by: Jiang/Powell-Coffman"|"Reference WBPaper00059755 added based on published strain data identified by Textpresso literature search."|"Supplementary_genotype hif-1(ia4), RE666 ire-1(v33), xbp-1(tm2482)"
Affected Gene: WBGene00001851(hif-1)
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Source: WormBase (RRID:SCR_003098)
Description: Central data repository for nematode biology including complete genomic sequence, gene predictions and orthology assignments from range of related nematodes.Data concerning genetics, genomics and biology of C. elegans and related nematodes. Derived from initial ACeDB database of C. elegans genetic and sequence information, WormBase includes genomic, anatomical and functional information of C. elegans, other Caenorhabditis species and other nematodes. Maintains public FTP site where researchers can find many commonly requested files and datasets, WormBase software and prepackaged databases.
URL: http://www.wormbase.org
Source Database: WormBase (WB)