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Proper Citation: IRESite (RRID:SCR_007754)
Description: The IRESite database presents information about the experimentally studied IRES (Internal Ribosome Entry Site) segments. Based on some experimental evidence there are at least 62 viruses and at least 90 eukaryotic cellular mRNAs reported to contain IRES. The experimental data about viral and cellular IRESs are contained in more than 189 and 318 publications, respectively. IRESite database covers at the moment 25 viral and 51 cellular IRES segments. Over 300 records contain the actual experimental results covering some of these IRESs in a greater detail. IRES regions are known to attract eukaryotic ribosomal translation initiation complex and thus promote translation initiation independently of the presence of the commonly utilized 5'-terminal 7mG cap structure. It is not yet clear whether the activity could be attributed to a common sequence or to a common secondary structure present in them. Such IRES regions were found in a broad range of +RNA viruses and in some eukaryotic cellular mRNAs. Certain IRESs have been predicted based on the fact that closely related viruses should share its features and indeed, their sequences are in some regions conserved enough to allow identification of a new IRES. In contrast, cellular IRESs do not have almost anything in common in terms of their sequence or secondary structure. Therefore, cellular IRESs cannot be predicted. Either way, IRESite is focused only on IRESs which have been at least to some extent experimentally proven. To allow the cross-correlation of the experimental results the IRESite database was specifically designed to store not only the primary experimental results (sequence, structure, measured values) but also the most important methodological characteristics of the experiments.
Synonyms: IRESite
Resource Type: data or information resource, database
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Source: SciCrunch Registry
Data set from Kravitz, Owen and Kretizer's 2012 paper "Optogenetic identification of striatal projection neuron subtypes during in vivo recordings."
