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dkNET community events and announcements in June, 2021

  • 11:26pm May 28, 2021
  • Ko-Wei Lin

Dear dkNET Community,

dkNET provides updates on activities of interest to the NIDDK-supported community. You could keep up to date on these activities through our Twitter feed @dkNET_info, through our Community Calendar, or through dkNET e-mail list. If you have an event or funding opportunities you'd like to advertise, please contact us info_at_dknet.org.


dkNET News

  • dkNET Webinar Series Recording and Slides of the dkNET webinar "Solving the Undiagnosed Diseases Network through Machine Learning”, presented by Dr. Zhandong Liu, are now available!

  • New Publication Congratulations! dkNET Hypothesis Center - Signaling Pathways Project (SPP) team lead Dr. Neil McKenna collaborated with the liver researchers and published a paper "A human liver chimeric mouse model for non-alcoholic fatty liver disease" in JHEP Reports. Scientists used SPP's NAFLD consensome to discover that NAFLD livers, compared to normal ones, have consistently higher levels of cholesterol synthesis enzyme transcripts! Check out this newly published paper: https://doi.org/10.1016/j.jhepr.2021.100281. SPP is also featured in the news of Baylor College of Medicine!

  • dkNET at Experimental Biology 2021 For those who attended EB 2021, thank you for visiting our virtual booth. We hope you all enjoyed the meeting. If you missed it, you can still visit our virtual booth until 5/31. Contact us via info@dknet.org if you have any questions. We have also created a new resource page including a collection of resources available at dkNET. Visit it now at https://dknet.org/virtual-booth!

  • New Resource added to dkNET
    • Microphysiology Systems Database (RRID:SCR_021126) is an open source database used for analyzing and modeling compound interactions with human and animal organ models. It is a platform for experimental design, data management, and analysis, and to combine experimental data with reference data, to enable computational modeling. It contains resource for relating in vitro organ model data to multiple biochemical, preclinical, and clinical data sources on in vivo drug effects.
    • Common Fund Data Ecosystem Portal (RRID:SCR_021197) is a portal allows researchers and clinicians to access and work across multiple Common Fund program data sets within digital cloud environment because biomedical research interaction with digital data is changing and no longer can large biomedical datasets be stored or analyzed using local computers and servers. It provides list of tutorials and resources to learn how to perform bioinformatic analyses and access data.

Events in June, 2021

Jun. 02-03, 2021

NIDDK Home Dialysis Workshop

Although maintenance dialysis started as a home-based therapy in the US in the 1970’s, it rapidly transitioned to a therapy delivered at dialysis centers that were concentrated on hemodialysis (HD). Over time, this led to a decrease in home-based therapy, which is overwhelmingly comprised of peritoneal dialysis (PD). Despite expanded use of home HD over the last decade, it only comprises a fraction of home dialysis. Patient choice is impacted, as the options for home-based dialysis are limited and have many more requirements than in-center based dialysis.
The NIDDK aims to identify research gaps and opportunities to advance the field of expanding choice and availability of home dialysis therapies by identifying current obstacles and potential avenues in which research may lead to solutions. Register by June 1, 2021.
More Information: https://www.niddk.nih.gov/news/meetings-workshops/2021/home-dialysis-workshop

Jun. 02-03, 2021

Heterogeneity of Diabetes Symposium: Beta Cells, Phenotypes and Precision Medicine

Celebrating the 100th anniversary of the discovery of insulin in 2021—Diabetes Symposium, Heterogeneity of Diabetes: Beta Cells, Phenotypes and Precision Medicine, June 2–3, 2021. This symposium will capitalize on diabetes research excellence and bring together research leaders to tackle the challenges and opportunities presented by investigation of the heterogeneity of diabetes and to inform on the next steps for research in this area. We look forward to this symposium facilitating engagement and stimulating collaboration among participants through discussions, highlighting critical knowledge gaps and novel approaches in diabetes research.
More Information: https://dknet.org/about/dknetnews/2244 


Jun. 02, 2021

Abstract Deadline: Kidney Week 2021

ASN will accept submissions for research abstracts and clinical case reports electronically from April 14, 2021 through June 2, 2021 (2:00 p.m. EDT). ASN requires ASN User Logins and completed financial and other relationship DISCLOSURES FOR ALL AUTHORS. Please allow adequate time to gather this information by June 2, 2021. 
More Information: https://www.asn-online.org/education/kidneyweek/2021/cfa.aspx 

Jun. 03-06, 2021

ASBCB Omics Codeathon

The National Institutes of Health Office of Data Science Strategy, in partnership with the African Society for Bioinformatics and Computational Biology (ASBCB(link is external)), is pleased to announce a virtual omics-focused codeathon on June 3-6, 2021.
More Information: https://datascience.nih.gov/news/request-for-proposals-asbcb-omics-codeathon 

Jun. 03, 2021

Heterogeneity of Diabetes Symposium: Twitter Chat

NIDDK's Dr. Cefalu, @normrosenblum, and diabetes research experts will be holding Twitter Chat on diabetes research on 6/3 at 9:00 am ET! Join using #Insulin100chat
More Information: https://twitter.com/NIDDKgov/status/1395047174325559298 


Jun. 03, 2021

State of the Science from the(sugar)science: Clinical, Pancreatic Transplant is Still Relevant for the Future of Type 1 Diabetes Care

Anchors: Mario Spaggiari MD(UIC), Colleen Jay MD (Wake Forest), Angelika Gruessner PhD (SUNY)

Panel: Camillo Ricordi MD (DRI), David Harriman MD (UBC), LJ Chen MD (U Miami)



Jun. 07-10, 2021

Indiana Center for Biological Microscopy Workshop

Due to COVID, the workshop will be presented online, with each day devoted to a specific interest area, and consisting of a morning symposium of lectures and a round-table discussion among experts in each field, followed by an afternoon of related online demonstrations.  While the online format has eliminated hands-on training, it has helped us assemble a stellar set of speakers.
More Information: http://medicine.iupui.edu/NEPH/OBRIEN/NEWWORKSHOP 

Jun. 09, 2021

DRC Virtual Seminar Series: Lessons from mouse models of bariatric surgery

The Virtual Diabetes Research Center Seminar Series began as an effort to connect investigators and trainees during this time of great change and isolation related to the COVID crisis. On June 9, 2021 Darleen Sandoval, PhD (Univ. Colorado) presents “Lessons from mouse models of bariatric surgery." More information: https://diabetes-virtual-seminar.org/


Jun. 15, 2021

22nd Annual Harvard Nutrition Obesity Symposium: Global Food Systems and Sustainable Nutrition in the 21st Century

The NORCH is pleased to announce the topic for this year’s symposium: Global Food Systems and Sustainable Nutrition in the 21st Century. We have an outstanding lineup of speakers who are experts in the fields of public health, global food systems, food inequity, and sustainable nutrition. The full list of speakers can be found below.
More Information: https://dev.norch.org/center-events/2021-symposium-global-food-systems-and-sustainable-nutrition-in-the-21st-century/


Jun. 16, 2021

LIPID MAPS Webinar: The Metabolic and Inflammatory-Induced Oxidation and Nitration of Unsaturated Lipids Yields Pleiotropic Electrophilic Adaptive Signaling Mediator

Presented by: Professor Bruce Freeman
Register at link below
More Information: https://www.lipidmaps.org/resources/tutorials/webinars/webinar/?code=lm_s2_bruce_freeman

Jun. 16, 2021

RDCA-DAP Professional Webinar Series: Value of Integrated Data and Analytics in Rare Disease Drug Development

The Rare Disease Cures Accelerator–Data and Analytics Platform is launching a new webinar series with the goal of sharing with the community examples of the use of rare disease person-level data in drug development and regulatory decision making. The series will feature 1-hour webinars highlighting analyses that have been done in individual disease areas, how they informed drug development, and how similar approaches could be applied to common drug development issues encountered in rare diseases. After each presentation time will be allowed for discussion with a panel of quantitative and regulatory experts around why the solutions presented were informative, lessons learned and how similar approaches could be applied to related problems.
Jun 16, 12pm ET Webinar Three: Understanding variability in rare disease populations: a case study of modeling disease progression in polycystic kidney disease to inform trial design.
More Information: https://criticalpath.webex.com/mw3300/mywebex/default.do?nomenu=true

Jun. 21-22, 2021

The 2nd Annual Interdisciplinary Nutrition Sciences Symposium (INSS)

Heterogeneity in Obesity: Implications for Cancer and Related Obesity-Associated Outcomes
Register at link below
More Information: https://www.interdisciplinarynutrition.org/



Jun. 23-25, 2021

NIDDK Cystic Fibrosis-Related Diabetes Scientific Workshop

Cystic fibrosis (CF) results from the dysfunction of the cystic fibrosis transmembrane conductance regulatory (CFTR) protein, which affects both bicarbonate and chloride transport. Although most commonly associated with lung disease, CF also is associated with diabetes. Cystic fibrosis–related diabetes (CFRD) now affects up to 50 percent of adult patients and is associated with significant increased mortality. The mechanisms by which CFTR dysfunction contributes to diabetes remain poorly defined. The CFRD Scientific Workshop, sponsored by the CF Foundation and NIDDK, is an online webinar to be held June 23–25, 2021. Registration deadline: June 14, 2021. 

More Information: https://www.niddk.nih.gov/news/meetings-workshops/2021/cystic-fibrosis-related-diabetes-scientific-workshop



Jun. 24, 2021

State of the Science from the(sugar)science: The Role of Genetic Susceptibility and Triggers in Type 1 Diabetes. Where Do We Go From Here?

Anchors: Stephen Rich PhD (UVA), Marian Rewers (UC), Doug Melton PhD (HSCI), Mark Atkinson MD (UF)

Panel: Jill Norris PhD (UC), Heikki Hyoty MD PhD (Tampere U)



Jun. 25-29, 2021

ADA 81st Scientific Session

We have made the decision to transition the 2021 Scientific Sessions to a virtual meeting, June 25-29, 2021. Attendees will receive exclusive access to all virtual content for 90-days after the event, with access ending September 29, 2021.The virtual 81st Scientific Sessions will continue to offer the latest groundbreaking science that you have come to expect from the ADA—so that, together, we can continue to help the 460 million people worldwide living with diabetes thrive.

More Information: https://professional.diabetes.org/scientific-sessions



Funding opportunities information and deadlines in June, 2021


Jun. 05, 2021

NIH Funding Opportunity Application Due Date: New Directions in Hematology Research (SHINE-II) (R01 Clinical Trial Optional)

This Funding Opportunity Announcement (FOA) seeks innovative grant applications in nonmalignant hematology research that will steer the field in new directions. Applications to this FOA should propose proof of principle research that is tightly focused into one specific aim, which can be accomplished within a 1-3 year project period, and is directed at validating novel concepts and approaches that promise to open new pathways for discovery.
More Information: https://grants.nih.gov/grants/guide/pa-files/pas-21-150.html 

Jun. 08, 2021

NIH Funding Opportunity Application Deadline: Gastrointestinal (GI and Microbiome Explorers: Development of Swallowable Smart Pills or Devices for Precision Nutrition, Microbiome and Digestive Disease (R21/R33 Clinical Trial Required)

The purpose of this Funding Opportunity Announcement is to support the development of tools/devices for sampling or monitoring of diet- gastro-intestinal (GI)(contents and mucosa) and microbial interactions (GI- Microbiome Explorer). It is anticipated that successful completion of the projects completed under this FOA will yield implementable devices/tools for gastroenterological research or other clinical applications, along with monitoring and sampling of GI contents and/or mucosa to examine diet-host-microbiome interactions for clinical research or diagnostic applications.

More information: https://grants.nih.gov/grants/guide/pa-files/PAR-20-133.html


Jun. 08, 2021

NIH Funding Opportunity Application Deadline: Development of Wearable Smart Devices for Continuous Monitoring of Circulating Nutrients, Metabolites and Hormones (R21/R33 Clinical Trial Required)

Recent advances in precision nutrition and circadian metabolism have come from studies utilizing continuous glucose monitors. However, diet leads to metabolic excursion of thousands of nutrients and metabolites, some linked to gut microbiota metabolism. Precision nutrition studies would benefit significantly from tools that can be used to monitor the metabolic excursions of other nutrients and metabolites in response to diet or other factors. Such data could help identify quantifiable links between the consumption of specific nutrients or food constituents and patho-physiological processes and the factors that impact health and disease susceptibility along with the factors leading to inter-individual variability in those links.

More information: https://grants.nih.gov/grants/guide/pa-files/PAR-20-134.html


Jun. 11, 2021

Kidney Precision Medicine Project (KPMP) Request For Information Response Deadline

KPMP would like to hear from you about what biomarker measurements they should perform on their stored KPMP samples. The objectives of the Kidney Precision Medicine Project (KPMP) are to ethically and safely obtain and evaluate human kidney biopsies from participants with AKI or CKD, create a kidney tissue atlas, define disease subgroups, and identitify critical cells, pathways, and targets for novel therapies.
More Information:  https://drive.google.com/file/d/1OgdSdVV6T4bXN_LZPEoZ_JlRl2_POHLJ/view

Jun. 12, 2021

NIH Funding Opportunity Application Due Date: HEAL Initiative: Notice of Special Interest (NOSI): Limited Competition to Support Mentorship of Junior Investigators

This Notice of Special Interest (NOSI) provides an opportunity for researchers funded by the Helping to End Addiction Long-Term (HEAL) initiative to devote more time to patient-oriented research and mentoring. For the purposes of the K24 award, patient-oriented research is defined as research conducted with human subjects for which an investigator (or colleague) directly interacts with human subjects. This area of research includes: 1) therapeutic interventions, and 2) clinical trials. NIH ICs participating in HEAL are issuing this notice to highlight their interest in receiving applications from HEAL investigators for a K24 award. The NIH defines a mentor as experienced scientist who can help guide the research of junior investigators and challenge them to develop independence as researchers. The objectives of mentoring include enhancing a mentee’s approach to scientific investigation, developing their critical thinking and communication skills and assisting with their progression within the research community.
More Information: https://grants.nih.gov/grants/guide/notice-files/not-ns-21-026.html

Jun. 15, 2021

NIH Funding Opportunity Letter of Intent Due Date: Cutting Edge Informatics Tools for Illuminating the Druggable Genome (U01 Clinical Trial Not Allowed)

The overarching goal of this funding opportunity announcement (FOA) for the Common Fund program "Illuminating the Druggable Genome" (IDG;https://commonfund.nih.gov/idg/ is to solicit applications to build a set of Cutting Edge Informatics Tools (CEITs) that will augment the capability of the IDG consortium's Knowledge Management Center (KMC) as well as the broader IDG Consortium. Application Deadline: July 15, 2021.
More Information: https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-21-020.html

Jun. 15, 2021

NIH Funding Opportunity Letter of Intent Due Date: Pilot Projects Investigating Understudied G Protein-Coupled Receptors, Ion Channels, and Protein Kinases (R03 Clinical Trial Not Allowed)

The goal of this funding opportunity announcement (FOA) for the Common Fund Program "Illuminating the Druggable Genome" (IDG; https://commonfund.nih.gov/idg/index) is to solicit applications for pilot projects on IDG-eligible understudied proteins (non-olfactory GPCRs, protein kinases, and ion channels) in order to study them beyond what the IDG’s Centers can accomplish and to validate and demonstrate the utility of IDG-generated reagents, data, and approaches. 
Application Deadline: July 15, 2021. 
More Information: https://grants.nih.gov/grants/guide/rfa-files/RFA-RM-21-012.html

Jun. 16, 2021

NIH Funding Opportunity Application Due Date: Development of Animal Models and Related Biological Materials for Research (R21 Clinical Trial Not Allowed)

This funding opportunity announcement (FOA) encourages innovative research to develop, characterize, and improve animal models, biological materials, and novel technologies to better understand human health and disease. This FOA also seeks projects aimed at improving the diagnosis and control of diseases that interfere with animal use for biomedical research. The proposed project must have broad application to multiple NIH Institutes or Centers (ICs) to align with the Office of Research Infrastructure Programs’ (ORIP) trans-NIH mission. The proposed studies must explore multiple body systems or evaluate diseases that impact multiple body systems. Applications that develop models focused on a specific disease or area of research, or only propose studies primarily relevant to a single NIH IC, will be considered not acceptable to this FOA and will be withdrawn.
More Information: https://grants.nih.gov/grants/guide/pa-files/PAR-21-167.html 


Jun. 22, 2021

NIDDK Funding Opportunity Application Due Date: Pilot and Feasibility Studies to Facilitate the Use of Diabetes Self-Management Education and Support to Improve Diabetes Care (R34 Clinical Trial Required)

The purpose of this funding opportunity announcement (FOA) is to test an innovative and pragmatic approach to address barriers to and facilitate greater use of diabetes self-management education and support (DSMES) by people living with diabetes mellitus. Research applications should engage key stakeholders in cultivating a practical and sustainable strategy with the potential for dissemination. The pilot trial of the proposed strategy should be designed to generate preliminary data in support of a future, full-scale trial to study broader dissemination and implementation to expand the use of DSMES. 
More Information: https://grants.nih.gov/grants/guide/rfa-files/RFA-DK-20-032.html 

Jun. 22, 2021

NIH Funding Opportunity Letter of Intent Due Date: Immune Cell Engineering For Targeted Therapy And Disease Monitoring in Type 1 Diabetes (R01 Clinical Trial Not Allowed)

This initiative will support the engineering of immune cells to target the human pancreatic compartment to report on previously inaccessible information about diabetes initiation and progression, and/or to deliver environment-specific therapeutic responses to restore islet health and prevent the progression to T1D.

NIH Funding Opportunity Application Due: The Autoantigens and Neoantigens Function in the Etiology and Pathophysiology of Type 1 Diabetes (R01 Clinical Trial Optional)

This Funding Opportunity Announcement (FOA) encourages applications from institutions and organizations proposing original research aimed at the characterization of the function of neoepitopes and neoantigens in type 1 diabetes. This includes the function that post-translational modifications might have in the humoral and cell mediated autoimmune responses and overall in the etiology and pathophysiology of type 1 diabetes. Applications that include the discovery of neoantigens or neoepitopes are within the scope of this solicitation, but should propose a plan for integrating these discoveries with the present knowledge on established epitopes and antigens (e.g. autoantibodies for insulin, GAD65, IA-2, and ZnT8). In the long-term the goals of this initiative are to facilitate the development of better tools to monitor disease progression and treatment, and potentially to facilitate the development of personalized therapeutics.
More Information: https://grants.nih.gov/grants/guide/rfa-files/rfa-dk-21-004.html

Jun. 24, 2021

NIH Funding Opportunity: Application Deadline Native American Research Centers for Health (NARCH) (S06 Clinical Trials Optional)

The National Institute of General Medical Sciences, in conjunction with the Institutes/Centers of the National Institutes of Health (NIH) listed above in the "Components of Participating Organizations" section and the Indian Health Service (IHS), invites applications from federally recognized Tribes and Tribal organizations for the Native American Research Centers for Health (NARCH) initiative. The objective of the NARCH initiative is to support biomedical research and career enhancement opportunities to meet health needs prioritized by American Indian/Alaska Native (AI/AN) communities.  The NARCH initiative also supports research capacity building and the development of research infrastructure to enhance the biomedical research capabilities of AI/AN communities.

More information: https://grants.nih.gov/grants/guide/pa-files/PAR-20-125.html


Jun. 29, 2021

NIDDK Funding Opportunity Application Due Date: NIDDK Central Repositories Non-renewable Sample Access (X01 Clinical Trial Not Allowed)

The NIDDK Central Repositories house valuable biological samples and data from numerous major clinical studies. This initiative allows investigators to apply for access to non-renewable samples from one or more of these studies. Information about the samples available can be found at https://repository.niddk.nih.gov. Applicants must provide a report from the NIDDK Central Repositories documenting sample availability. Letter of Intent due 30 days prior to application due date.
More Information: https://grants.nih.gov/grants/guide/pa-files/PAR-19-319.html


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The NIDDK Information Network (dkNET) serves the needs of basic and clinical investigators by providing seamless access to large pools of data and research resources relevant to the mission of The National Institute of Diabetes Digestive and Kidney Diseases (NIDDK). dkNET is hosted at University of California San Diego, and is supported by NIH NIDDK grant 2U24DK097771-09.

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