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Project Team and Advisors

Project Team

Maryann Martone, dkNET PI

Dr. Martone has a BA from Wellesley College in biological psychology and a Ph. D. in neuroscience from the University of California, San Diego, where she is currently a Professor in the Department of Neuroscience. Her background is in neuroanatomy, particularly light and electron microscopy, but she spends most of her time now in the field of neuroinformatics. She is the principal investigator of the Neuroinformatics Framework project, a national project to establish a uniform resource description framework for neuroscience. Her recent work has focused on building ontologies for neuroscience for data integration. She heads the International Neuroinformatics Coordinating Facility (INCF) program on ontologies. She is the president of FORCE11, an organization dedicated to advancing scholarly communication and e-scholarship.

Jeffrey Grethe, dkNET PI

Dr. Grethe has a BS from the University of California Irvine in Applied Mathematics and a Ph.D. in Neuroscience, with a focus on bioinformatics, from the University of Southern California. Throughout his career, his primary focus has been on enabling collaborative research, data sharing and discovery through the application of advanced informatics approaches. Before coming to UCSD he was one of the core members responsible for bringing the fMRI Data Center online, the first publicly accessible repository of peer-reviewed fMRI studies. He is currently leading a number of large scale biological and biomedical informatics projects (i.e. PI for the NIDDK Interconnectivity Network Coordinating Center, co-PI for the Neuroscience Information Framework, and Technical Lead for the Community Cyberinfrastructure for Advanced Microbial Ecology Research and Analysis) in the Center for Research in Biological Systems at the University of California, San Diego.

Ko-Wei Lin, Project Manager

Dr. Lin has a DVM from National Taiwan University and a PhD in Comparative Biomedical Sciences, focusing on Cell Biology, from North Carolina State University. Her post-doctoral training at University of California San Diego were both in Biomedical Sciences focusing on inflammatory and immune pathways, and in Biomedical Informatics. She also has extensive experience in bridging the biomedical sciences and informatics -e.g. through information model development and validation, user outreach, and user requirement analysis for developing information retrieval tools.

James Go, Web Developer

James has a BS in Cell and Molecular Biology from Cal State Northridge. He previously worked as a researcher and web developer at UCLA where he analyzed epigenetic and proteomic data and created web interfaces for collaborating researchers to access their data.

Sean Penticoff, Systems Support

Sean is a systems engineer working for the Center for Research in Biological Systems at the University of California, San Diego. He has 10+ years of experience working on system integration and configuration management.

Chun-Nan Hsu

Stephanie Hagstrom

Vicky Guo

NIH NIDDK Program Staff

Silva Corinne, Ph.D., Project Scientist

As Program Director of Signaling and Nutrient Sensing, I oversee a portfolio of grants that are focusedon elucidating the role of nutrient sensing signaling pathways in the development and/or progression of insulin resistance, type 2 diabetes, obesity, and metabolic disease. Studies involve the identification of regulators, interacting partners, and substrates to elucidate modes of signal transmission, including circadian regulation, that impact physiological systems and result in metabolic dysfunction. A particular focus is on the nuclear hormone receptor superfamily, a unique class of proteins that regulate an array of molecular functions including metabolic homeostasis. In addition, I oversee a growing portfolio of research grants that focuses on the role of the intrauterine environment in metabolic disease of the offspring. These grants include both basic and translational studies that investigate the mechanisms by which the intrauterine environment alters metabolic responses in the offspring including, but not limited to, intracellular signaling pathways, inflammatory cytokines, nutrient sensing pathways, and epigenetic imprinting. The ultimate goal of this research is to identify molecular targets that could be used therapeutically to prevent metabolic disease.

Xujing Wang, Ph.D., Program Director

As the program director for data science and computational biomodelling, I manage a research portfolio of projects that develop methods and tools that enable the utilization of data science in, that utilize high-throughput (Big) data in, and that develop computational, or joint computational and laboratory approaches to model biological processes relevant to, diabetes and metabolic disease research, or any other area of disease or biology of relevance to the DEM mission. I am also the program director for HIRN-CBDS, HIRN-HPAP, dkNET, and co-program director for TEDDY.

NIH NIDDK Ad Hoc Advisors

Kristin Abraham, Ph.D.

My portfolio includes research grants focused on the role of inflammation in diabetes and projects developing animal models to enhance basic and preclinical research in diabetes, endocrinology, and metabolic diseases. I also play an active role in the Mouse Metabolic Phenotyping Centers Program, the Diabetic Complications Consortium, and in the second phase of the KOMP2 Knockout Mouse Project. In addition, I am a member of the Common Fund High-Risk High-Reward working group that assists with oversight of the NIH Director's HRHR portfolio including the Pioneer, New Innovator, Early Investigator, and Transformative R01 programs

Arthur Castle, Ph.D.

I direct programs that study metabolomics and informatics. As such, I manage a research portfolio that applies technology to measure the large-scale integrated metabolism of cells, tissues, and organ systems. These studies measure and identify many metabolites within multiple pathways and aim to discover new relationships between metabolite profile changes and the pathology of specific metabolic diseases or syndromes. I am a co-coordinator of the Common Fund Metabolomics Initiative. The NIH Common Fund addresses key roadblocks in biomedical research that impede basic scientific discovery and its translation into improved human health. As director of the training program, I manage a research portfolio of fellowships and institutional training grants in diabetes, endocrinology, and metabolism. These fellowships and training appointments provide stipend support for predoctoral and postdoctoral students and fellows doing research in NIDDK mission-related fields. As the informatics director, I manage a research portfolio of bioinformatics and modeling grants and serve on committees related to bioinformatics.

External Scientific Advisory Panel

Director of Biomedical Informatics & Alliances, Clinical Data Interchange Standards Consortium (CDISC), and Assistant Professor, Baylor College of Medicine
Department of Obstetrics and Gynecology, UT Southwestern Medical Center
Associate Director, Center for Biotechnology and Genomic Medicine, Augusta University
Andrea de Souza, Ph.D.
Director, Informatics & Data AnalysisBroad Institute, Broad Institute

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