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The CTRC Sleep Core provides services in support of clinical sleep research. It is based at two sites: the CHOP Sleep Laboratory, convenient to the CTRC Outpatient Facility on the 7th Floor of Main Hospital and the University of Pennsylvania?s Sleep Laboratory, located on the 11th Floor of the Gates Building which is part of the medical complex of the Hospital of the University of Pennsylvania. The Sleep Core contains a total of six designated research beds, dedicated staff, and state-of-the-art equipment that provides support for a variety of sleep-related research initiatives. Studies performed in the Sleep Core include overnight polysomnography, multiple sleep latency testing, neurobehavioral testing and actigraphy. The Sleep Core��s goals include providing highest-quality sleep studies, extending sleep research to disciplines not traditionally involved in this area, further developing extant multidisciplinary programs, and offering training opportunities for medical students, residents, fellows, and junior faculty in clinical sleep research. The Sleep Core is associated with CHOP?s and UPHS? American Academy of Sleep Medicine-accredited Sleep Center Laboratories. Services for pediatric and adult subjects: * Study Design * Overnight Polysomnography ** Polysomnography Interpretation * Multiple Sleep Latency Testing * Actigraphy * Neurobehavioral testing * Sleep Core Library

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Outpatient study facility access, iDXA scan service, Research specimen processing, Research specimen storage, NIH/Industry clinical trial support, Pharmacy laboratory access, Adipose biopsy, Patient assessment and monitoring, Metabolic testing service, Phlebotomy, Support for bone marrow biopsies. The Clinical and Translational Research Center (CTRC) has two main locations as well as satellite locations. The protocols cover a wide variety of research areas including: HIV, sleep disorders, cholesterol, obesity, diabetes, various cancers, arthritis, hypertension, renal disease, short bowel syndrome, and neonatal and surgical studies as well as new treatments for various diseases. The CTRCs service over 1200 inpatients and over 6000 outpatients a year. Research subjects range from premature infants to the elderly, with the majority of adults being seen at HUP. HUP Unit - Dulles Building: * 8 bed inpatient * 8 chair and 2 bed outpatient unit * metabolic kitchen * Scatterbed nursing services throughout hospital units including the ICUs, ED and operating rooms UPPMC Unit ? 1st Fl Mutch Building: * 18 outpatient treatment beds * metabolic kitchen <b>CHOP Units:b> * 4 bed inpatient unit - 5 West Main * outpatient unit with 2 treatment rooms, 4 treatment chairs and a consultation room - Main 7 * Scatterbed nursing services in Newborn Nursery - Ravdin Building The nurse manager should be contacted prior to submitting a new protocol submission to the CTRC and discussions should continue throughout the start-up process.

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• SciCrunch
• 13 years ago - by Anonymous

A top-domain ontology that provides definitions for the foundational entities of biomedicine as a basic vocabulary to unambiguously describe facts in this domain. It can furthermore serve as top-level model for creating new ontologies for more specific domains or as aid for aligning or improving existing ones.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. Core whose main aim is to provide vector technology for preclinical studies and other basic research applications. Its services include rovision of AAV, adenoviral and lentiviral based vectors, consultation and advice in the design of custom vectors and in vector serotype/pseudotype selection, and design, cloning and production of plasmid DNA for the production of custom vectors.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Brain MRI service. Researchers in the Neuroscience and Magnetic Resonance Research Program are using a research dedicated 3-Tesla scanner to study the human brain and brain diseases. Facilities: The Magnetic Resonance (MR) Processing Core serves the needs of researchers in the MR Research Facility at Queen''s Hospital. Specifically, the MR Image Processing Core provides image processing support, infrastructure development, methodological development and training; expertise is available.

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• SciCrunch
• 13 years ago - by Anonymous

Mouse core which generates transgenic and gene-targeted mouse lines for diabetes research.

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• SciCrunch
• 13 years ago - by Anonymous

Offers in vivo services specializing in immunodeficient and xenograft models (PDX, humanized immune system). Facility has dedicated BSL2 barrier space equipped with optical imaging, for applications ranging from immunotherapy, cancer biology, infectious diseases and regenerative medicine. Offers services centered around repository of live and fully annotated cells from adult patients with hematologic malignancies (AML, ALL, MPN, MDS), and hematopoietic stem/progenitor cells from healthy donors (BM, CB, and FL).

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Contrast enhanced sonography, Quantitative analysis of images, Small animal ultrasound imaging, Blood flow velocity measurement, Tissue motion measurement. The Ultrasound Sub-Core of the SAIF offers an array of research services for pre-clinical research including quantitative image analysis and consultation. Our state-of-the-art ultrasound scanners are available as a resource for conducting your research studies. This rich resource for ultrasound imaging is available at nominal hourly fees for various categories of study. Ultrasound Research Services provides services to a host of groups working on diverse projects such as the measurement of angiogenesis, vascularity, tissue elasticity, the effects of various pharmaceuticals on these measures and more. Such research encompasses a variety of clinical areas including radiology, oncology, cardiology, gynecology, and hematology, among others.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Optical/bioluminescence in vivo imaging, Small animal bioluminescence/fluorescence imaging support services. The Optical/Bioluminescence Sub-Core of the SAIF provides the capability to perform cellular and molecular non-invasive in-vivo bioluminescence, fluorescence or near-infrared imaging. The instrumentation allows sensitive, non-invasive molecular imaging for a variety of applications including detection and quantification of various bioluminescent or fluorescent reporter-expressing cells or tissues (in culture or in small animals). The facility currently houses a Perkin Elmer IVIS Lumina II, two LI-COR Pearl Impulse Imagers and a Perkin Elmer IVIS Spectrum. The Facility offers assistance with experimental design, regulatory approval, troubleshooting, data management, analysis and display.

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• SciCrunch
• 13 years ago - by Anonymous

The MR Sub-Core of the SAIF provides the instrumentation and expertise necessary to perform a broad spectrum of magnetic resonance imaging and spectroscopy studies on a wide range of biological samples including small animals (cats, rabbits, rats, mice), tissue specimens, cultured cells and tissue extracts. This facility includes a conveniently located, well equipped surgery room used for preparing the animals for MR exams and a wide assortment of supporting equipment, i.e. anesthesia machines, MR compatible vital signs monitors (SA Instruments), infusion pumps (Harvard), heating pads, etc. A variety of perishable supplies used in animal preparation are provided by the facility.

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• SciCrunch
• 13 years ago - by Anonymous

A structured controlled vocabulary for the source of an enzyme. It comprises terms for tissues, cell lines, cell types and cell cultures from uni- and multicellular organisms.

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• SciCrunch
• 13 years ago - by Anonymous

The Small Animal Imaging Facility (SAIF) of the University of Pennsylvania provides multi-modality radiological imaging and image analysis for cells, tissues, and small animals. The SAIF combines state-of-the-art instrumentation and a nationally recognized staff to assist investigators with a wide range of imaging based experimental approaches. The SAIF currently provides a comprehensive suite of imaging modalities including: magnetic resonance imaging (MRI) and spectroscopy (MRS), optical imaging (including bioluminescence, fluorescence, and near-infrared imaging), computed tomography (CT), positron emission tomography (PET), single photon emission computed tomography (SPECT), and ultrasound (US). In addition, dedicated housing is available for mice and rats undergoing longitudinal imaging studies. Ancillary facilities and resources of the SAIF are devoted to chemistry, radiochemistry, image analysis and animal tumor models, including assistance with animal handling.

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• SciCrunch
• 13 years ago - by Anonymous

The Penn Regional Nanotechnology Facility (PRN) is a full-service center equipped with a wide range of state-of-the-art instrumentation for materials analysis. Nanoscale characterization of polymers, ceramics, composites, metals, electronics, and thin films is conducted using scanning, transmission, and scanning-transmission electron microscopes, atomic force microscopes, and ion scattering techniques. A wide range of specimen preparation equipment is used including cryo-ultramicrotomy, jet electrolytic polishing, mechanical dimpling, ion beam thinning, tripod polishing, vacuum evaporation, sputter-coating and replication. Both analog and digital output are produced and in-house hardware and software are available for a wide range of image and spectrum processing tasks and for the calculation/simulation of electron-beam specimen interactions and microscope performance. The Nanotech Facility is setup to accommodate both academic and corporate users. Users have the option of working with a staff member or they may take advantage of our comprehensive user training in order to work independently on the instrument of their choice. Please feel free to contact us for any questions or comments about our facility.

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• SciCrunch
• 13 years ago - by Anonymous

Core which offers high quality immunoassay services to basic, translational, and clinical investigators performing diabetes and related metabolic disease research. The core also provides consultation and training and education services.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: 2D-DIGE equipment access, Trypsin digestion, Metabolite profiling by mass spectrometry, Biomarker quantification by mass spectrometry, Proteomics analysis service. The Proteomics Core Facility in the Penn Genomics Institute is a service and collaborative research resource that balances applied proteomics research with the development of new and improved methods for protein identification, characterization, and quantification. The facility encourages collaborations that apply the tools of proteomics to cutting edge biomedical research. The Proteomics Core Facility is a center not only for services but also for basic and collaborative research and development of two-dimensional gel electrophoretic - and mass spectrometric-based techniques. Prospective users are encouraged to make their inquiries either by e-mail (ian@spirit.gcrc.upenn.edu), or stop by our facility on the eighth floor of BRB II/III.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Sequencing sample preparation service, Illumina sequencing service, Initial analysis of sequencing data, Next-generation sequencing data delivery. The NGSC offers ultra high throughput sequencing services for the Perelman School of Medicine research community. We offer library quality assessments, sequencing, and optional preliminary data analysis for a wide variety of experimental protocols including ChIP-seq, RNA-Seq, HITS-CLIP, miR-Seq, exome capture, and BIS-seq. We offer limited library preparation services, but can advise on library preparation techniques. We have two Illumina hiSeq2000s for large-scale sequencing and a MiSeq for sample evaluation or library testing. To get started, visit our website, create an account for yourself, then create a new experiment and we will contact you.

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• SciCrunch
• 13 years ago - by Anonymous

Blog presenting news and information, and spur discussion about topics related to RNA-Seq.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Behavioral testing training, Behavioral testing consultation service, Neurobehavior Testing Core access, Evaluation of anxiety behavior, Evaluation of circadian activity and rest/activity patterns, Measurement of sleep/wake patterns, Video image analysis of behavioral assays, Tissue harvest and histology prep service, Customized behavior batteries. The Neurobehavior Testing Core provides core facilities and services to test mice in state of the art assays of simple and complex behaviors, including the assessment of circadian rhythms and sleep, learning and memory, motor and sensory function, as well as behavioral assays relevant to translational studies of neurological, neurodevelopmental and psychiatric disorders. The core offers comprehensive behavior phenotyping of your mice or can train your lab personnel to perform the tests in the facility. In addition, we provide consultation on study design including appropriate tests, mouse line/strain, numbers of animals, control groups and breeding strategies. The core will also provide consultation regarding ULAR, IACUC and other regulatory issues. Assistance with data analysis is also available. The behavior apparatus available in the core includes: running wheels and beam splitters to measure circadian activity and rest/activity patterns as well as EEG/EMG recording chambers to measure sleep/wake states. Motor function is assessed using open field activity monitors and Rotarod. Apparatus to measure anxiety-like behavior including zero maze, light/dark chamber, passive/active avoidance chambers and hole poke arenas are also available. Extensive assessment of cognition, learning and memory is conducted with Morris water maze, radial arm maze, 5 choice serial reaction time test and object recognition tests. Tests of behaviors associated with depression (forced swim), schizophrenia (startle/PPI), social interaction (choice and social memory), and drug addiction (conditioned place preference) are also available. Tests of general health and responsiveness are also performed, as these are critical for the evaluation of complex behavior. Support for the core is provided by the Comprehensive Neuroscience Center, the Institute for Translational Medicine and Therapeutics, the Center for Sleep and Circadian Neurobiology and the Perelman School of Medicine.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: NBIC instrumentation training, Scanning probe measurement service. The NBIC serves as an incubator for new probes of nanostructure behavior and associated instrumentation development. It is equipped with a suite of scanning probes, opto-electronic/transport tools, and optical probes that are so recently developed as not to be available on commercial instruments. The environment facilitates the development and refinement of new probe-based techniques.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Desktop sequence analysis tools subscription, Database and web applications support, Genomic-scale sequencing analysis, Sequence analysis application support, Transcript profiling consultation service, Transcript profiling application support, Transcript profiling data analysis, Automating large or repetitive tasks, Web space for biological databases, Bioinformatics/genomics resource identification, and Data storage. The bioinformatics staff of the Penn Molecular Profiling Facility is available to provide experimental design and analytical services to users of the Facility and the basic and biomedical research community. Additional services are provided, including grant support, data management and custom computational projects. This facility provides one-on-one training and hosts instructional workshops. Their goal is to ensure that scientists across the University are able to exploit existing and emerging computational technologies, especially related to their genomics scale datasets.

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• SciCrunch
• 13 years ago - by Anonymous