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Core facility that provides the following services: Hematology Services, Parasitology Services, Chemistry Analysis Services, Cell Line Testing, Customizable Chemistry Analysis, Phenotyping Services, Infertility evaluation in male mice, Veterinary Pathologist Consultation. Access to consented and de-identified human tissue specimens; Comprehensive, state of the art diagnostic, necropsy and comparative pathology services for animal model systems with specific expertise and focus on mouse models; Research histology including advanced techniques, immunohistochemistry, immunofluorescence, laser capture micro-dissection and tissue micro-array preparation; Access to experts in veterinary and human pathology.

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• SciCrunch
• 13 years ago - by Anonymous

Vanderbilt Transgenic Mouse/Embryonic Stem Cell Shared Resource (TMESCSR) provides services that facilitate the generation, storage and regeneration of genetically altered mice.

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• SciCrunch
• 13 years ago - by Anonymous

The Tissue Core laboratory provides direct proteome profiling and protein imaging of intact tissues by MALDI-MS. The Core also provides proteome profiling of biofluids by MALDI-MS as they pertain to a specific disease.

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• SciCrunch
• 13 years ago - by Anonymous

Provides support for phone interview-based collection of information from study subjects. The Survey Research Shared Resource provides services to investigators related to development and implementation of mail, telephone, web and mixed mode surveys.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Polysomnography, Titrations with continuous positive airway pressure, Multiple sleep latency testing, Wrist actigraphy, Video polysomnography. The Vanderbilt Sleep Research Core offers two hard-wired sleep systems with synchronized video-polysomnography and 21 channels of EEG, with dedicated registered sleep technologists. A sleep core/sleep reading center manager and the core director (Dr. Beth Malow) assist investigators with protocol development. It offers polysomnography, titrations with continuous positive airway pressure, multiple sleep latency testing, and wrist actigraphy (wireless devices that measure sleep-wake patterns non-intrusively based on accelerometers that measure activity vs. rest). The core provides for centralized scoring of polysomnography and actigraphy data for multicenter trials. In addition to the scoring component, emphasis is placed on the quality of the sleep recordings at the individual sites with close communication among the individual site technologists and the sleep core manager.

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• SciCrunch
• 13 years ago - by Anonymous

The Rat Neurobehavioral Core provides equipment, training and consulting for Vanderbilt personnel who are interested in studying rat models of both neurological and psychiatric disorders. Examples of assays available for research in rats include models of anxiety, depression, drug abuse, learning and memory, cognition, attention, social interaction, pain, motor activity and coordination. Investigators can employ the latest technology in video capture and software-based analysis of behavior. Additionally, the facility offers a 24 hr/day home cage monitoring system that includes measurement of sleep EEG and core body temperature. A surgical suite is available, outfitted with a wide variety of equipment such as standard rat stereotaxic frames and a stereo-microscope, as well as various perfusion tables. Housing takes place inside the facility?s vivarium, which is Virus-Antibody free.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Immunophenotyping, Fluorescent protein expression analysis, Cell-cycle analysis, Functional assay service, Non-infectious cell sorting, BSL2+ biohazardous cell sorting, Flow cytometry consultation service, Flow cytometry training and ongoing advice, Flow cytometry data management service, Flow cytometry collaboration facilitation, Flow cytometer access. The Wistar Institute Flow Cytometry Shared Resource provides flow cytometric services, training, advice, and support for the use of flow cytometric techniques by Wistar Cancer Center investigators, as well as the greater basic research community.

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• SciCrunch
• 13 years ago - by Anonymous

The Neurochemistry Core Lab performs assays of neurotransmitter concentrations in brain tissue, designs custom assays as well as provides training in HPLC methods.

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• SciCrunch
• 13 years ago - by Anonymous

The objectives of the physiology core are to establish average values and normal ranges for physiologic parameters of renal function in mice, and to develop novel assays of mouse kidney structure and function. Our goal is to provide valuable institutional and national shared resources to facilitate better understanding of kidney diseases and treatments.

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• SciCrunch
• 13 years ago - by Anonymous

The overall goal of the Histology and Morphometry Core is 1) to provide a common facility and expertise for the broad spectrum of morphologic studies that may be required for interpretation of studies of various models of kidney disease and their response to interventions; 2) to provide tissue samples from existing archival specimens from various mouse and rat kidney disease models that may be used for exploration and characterization of expression patterns of various novel target molecules; and 3) to develop and enhance existing morphologic techniques to improve the ability of center investigators to localize specific molecules and tissue sections, and to interpret their significance based on the spatial localization and relationship to patterns of injury.

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• SciCrunch
• 13 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. Core facility that provides training and expertise in nutrition/diet methodology to obtain valid and reliable assessment and analyses of dietary intakes, nutritional status, body composition and metabolism.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Simple Protein Identification, Multidimensional Protein Identification Technology, 2D Difference Gel Electrophoresis (2D-DIGE). The Proteomics Laboratory provides state-of the-art MS instrumentation and analytical methods to analyze proteins and proteomes.

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• SciCrunch
• 13 years ago - by Anonymous

Our mission is to provide cost effective, state-of-the-art instrumentation to students, fellows and faculty for identification and structural analysis of biological molecules and for qualitative and quantitative assays of drugs and metabolites in physiologic fluids. Our aim is to provide a collegial and cooperative environment in which to do research.

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• SciCrunch
• 13 years ago - by Anonymous

Mass spectrometry is used to analyze the complex array of lipids in cellular membranes in an effort to dissect precursor-product relationships in lipid signaling networks.

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• SciCrunch
• 13 years ago - by Anonymous

The Vanderbilt Institute of Nanoscale Science and Engineering (VINSE) is a University institute focused on new science and technology based on nanoscale materials. We carry out frontier science and technology by teaming locally and globally, and providing an environment where physicists, chemists, biologists, and all engineers may collaboratively solve forefront problems and create new scientific understanding.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Photolithography Laboratory, Device Fabrication Laboratory, VIIBRE Machine Shop, VIIBRE Electronics Shop. The VIIBRE Microfabrication Core offers facilities and expertise for the design, manufacture, and implementation of micro- and small-scale electronic, mechanical and fluidic devices. Typical products include fluidic networks,pumps and valves, arrays of microfabricated traps for cellular study, implantable devices for in vivo imaging, liquid and gas control systems, biological habitats, environments and microbioreactors, and more.

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• SciCrunch
• 13 years ago - by Anonymous

Biochemical Substructure Ontology

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• SciCrunch
• 13 years ago - by Anonymous

VIIBRE''s Automated Biosystems Core (VIIBRE-ABC) provides a powerful technical foundation for the study of dynamic cellular metabolism, signaling, and control, with more than $4.7 million received from the Defense Threat Reduction Agency (DTRA), the National Institute on Drug Abuse (NIDA), the NIH Shared Instrumentation Program, and Vanderbilt University. An important focus of this effort is to explore dynamic host responses to chemical agents, toxins, and microbial pathogens. The ABC comprises two major instruments: a custom Omni-Omics system built around a Waters Synapt G2 UPLC/GC/ESI/nESI Ion Mobility-Mass Spectrometer, and a microfluidics-enabled high-content screening system built around a Perkin Elmer Opera QEHS Automated Confocal Microscopy System.

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• SciCrunch
• 13 years ago - by Anonymous

The mission of the Innovative Translational Research Shared Resource (ITR) is to advance the translation of basic and clinical research into improved clinical therapies by facilitating clinical discoveries and managing laboratory and clinical data exchange between researchers. The ITR has partnered with the Personalized Cancer Medicine Initiative (PCMI) and the Vanderbilt-Ingram Cancer Center (VICC) to characterize the molecular changes present in tumors. With a focus in clinical sample preparation and tumor genetic analyses, the ITR uses the most advanced laboratory techniques to uncover the genetic uniqueness of each patient''s tumor for research. This knowledge will lead to improved clinical therapies and a more personalized cancer care that will save lives and improve patient outcomes. The ITR gives scientific and technical assistance to clinical and laboratory researchers interested in experimentation using human tumor tissues or cell lines. In addition to our expertise in genetic analyses, the ITR is also interested in partnering with clinical investigators to study clinical phenotypes in a research laboratory. These studies are tailored to the needs of the clinical investigator.

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• SciCrunch
• 13 years ago - by Anonymous

Core facility that provides the following services: Cytometric Bead Array, Meso Scale Discovery''s Multi-Array��, Cytometry protein measurements, Elispot Assays, Phenotypic analysis with flow cytometry, Multifunctional/Polychromatic flow cytometry (7-14 color), Cell proliferation assays, Tetramer/pentamer staininng, Influenza hemagglutination inhibition assay, Bordetella pertussis ELISA IgG / IgA, Commercial ELISA. The Immunology Core provides assistance to investigators with sample processing, storage, shipping, documentation, assay design, assay development and evaluation of immune responses. It is the goal of the core to monitor immune responses during clinical trials using the latest advances in technology and provide practical applications of this technology to evaluating immune responses. We continue to develop new immune monitoring technology with industry and academic collaborators. The Immunology Core has extensive experience in assay development and optimization, and will assist in the selection of appropriate assays and antigens during the protocol/developmental phase of a study or trial.

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• SciCrunch
• 13 years ago - by Anonymous