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THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July,27,2022. Core facility that provides scientific and budgetary oversight for all CCEH activities. This includes training programs, high school summer internships, and and pilot and feasibility program for new projects.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which provides mouse models and a biobank of tissues and other materials for research.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core which supports the work of the Baltimore Polycystic Kidney Disease research center by providing antibody validation services and vectors to researchers.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core facility which provides emerging technologies in hematology and relevant training for junior investigators. Its services include in vitro hematopoiesis assays services, automated complete blood counts, morpholoigcal analyses, CRISPR based genomic editing, and FACsorting and analysis.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core whose goals include to characterize mouse models of HRFD in vivo, establish mTERT and hTERT immortalized cell lines, and the physiological and molecular characterization of HFRD cell lines.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center for research in polycystic kidney disease (PKD) with collaboration by international investigators. The center has several cores, including biomedical cores for antibody validation and cell cultures, educationa programs, and pilot programs for new projects.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core goals include to develop in vitro predictive assays to identify and characterize HRFD lead compounds, develop in vivo predictive translational HRFD models to enhance efficacy assessment in preclinical testing, and develop advanced HRFD-specific toxicology and safety screens.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center that concentrates on the common, adult form of the disease, autosomal dominant PKD (ADPKD). The services provided focus on understanding the genetic basis of disease, more accurately monitoring disease progression and improving prognostics, and employing model systems to explore pathogenesis and conduct preclinical testing.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that makes available PKD model systems and technologies to PKD researchers at Mayo and at other institutions. Its services include C. elegans PKD-targeted services, Zebrafish PKD-targeted services, and Rodent PKD-targeted services.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center that focuses on understanding the causes of Cystic Kidney Disease and other related disorder and the development of new therapeutic strategies.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core whose goals include Generation of New Animal and Cell Models of HRFDs, to establish In Vivo Biosensors to Study Signaling Pathways Involved in HRFD Ciliopathies, and to generate and distribute HRFD Related Biologicals to the Center?s Investigator Base.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core whose goals are to establish a national resource for clinical data, DNA, and tissue biopsies from human patients with HRFDs, develop algorithms to identify causative genetic mutations in HRFD patients and utilize a suite of new tools to assess the pathogenicity of sequence variants, and expand the portfolio of educational information and tools to encompass the HRFD spectrum of disorders.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core services include mutation screening of cell lines derived from ADPKD patients, mutation screening of large, typical ADPKD populations, genetic screening of atypical PKD families, cystic Kidney and Liver Disease Biobank (CKLBB) from ADPKD patients, and urine collection and fractionation.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center for the study of the development of the kidney during embryonic, fetal and postnatal life. As a collaboration between the University of Virginia and Tulane University, they use an interdisciplinary and inter-institutional approach for their research.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core that provides quantitation and identification of protein changes by 2D gel-based methods and isotope tagging and nanoLC-MS/MS, identification of protein biomarkers detected from biofluids in the Biomarker Core, and provision of dedicated and expert Biostatistical and Bioinformatic support for data analysis.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

A portal with detailed information about various research centers that focus on kidney disease and translational research funded by NIDDK.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core provides semiautomated MRI and computed tomography (CT) image and volumetric analyses of polycystic kidneys and liver as well as functional assessment of the kidney and heart, including measurements of renal blood flow. It also facilitates the transmission, collection and storage of anonymized imaging data used in translational PKD research and provides a system that enables PKD researchers to exchange images.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center that emphasizes diagnosis, treatment and management of all types of nephrologic and hypertensive disorders in infants, children, and adolescents. Therapies range from medical management to renal replacement therapy.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Center whose goal is to support basic, translational, and clinical research on critical pediatric kidney diseases by focusing on Acute Kidney Injury, Nephrotic Syndrome, and Lupus Nephritis.

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• SciCrunch
• 10 years ago - submitted by Kristen Jensen

Core aims include to empower the Nephrology Center of Excellence investigators by providing access to integrated state of the art gene expression technologies with which to apply genomics methods to accelerate molecular nephrology research, educate, assist, and improve the use of global genomics approaches, infrastructure and specialized tools for the enhancement of research productivity and discovery by the Nephrology Center of Excellence investigators, and develop and disseminate specialized data sets and the use of advanced analytic techniques and/or protocols to facilitate translation of research data to accelerate basic and applied research and its translation to improved clinical care.

• Resource
• SciCrunch
• 10 years ago - submitted by Kristen Jensen