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Core for protein expression and purification as well as all equipment needed for determination of three dimensional structures of biological macromolecules via X-ray crystallography. Houses Rigaku/MSC microMax 007HF generator for X-ray diffraction data collection, equipped with Varimax optics, X-stream 2000 cryosystems and two RaxisIV++ detectors.Also available is stereomicroscope, Nikon SMZ18, for crystal tray observations and crystal mounting., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Facility provides mass spectrometry analysis of proteins. Provides access to mass spectrometry based proteomics technologies and services including Protein Identification, Molecular Weight Determination, Quantitative Protein Analysis, Post-translational Modification Analysis, LC or LC-MS Analysis, Equipment Usage, Additional Data Analysis:Bioinformatics, statistics, pathway analysis and Assistance preparing materials for manuscripts or grants.Consultations for custom assays for other MS Services are also available.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Core provides protein and small molecule structural and functional analysis, and quantitation using technologies and software applications. Services in Nano-liquid chromatography,Protein identification and quantitation using SWATH,Protein post translational modification identification,Lipid profiling and identification (MS/MSALL),Targeted multiple reaction monitoring (MRM) for lipids.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Core to produce genetically modified mice, rats, and stem cells for the UMMS Scientific Community.Composed of two facilities: Animal Modeling Facility and Gene Targeting and Stem Cell Facility.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Core provides consultation services to assist researchers in designing imaging studies, limited labeling services and data acquisition and analysis.Core offers following services:Single Photon Computerized Tomography (SPECT),Positron Emission Computerized Tomography (PET), X-Ray Computerized Tomography (CT),NIR Optical Imaging of small animals.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Facility houses complete collections of human and mouse lentiviral short hairpin RNA (shRNA) libraries from Open Biosystems/GE Dharmacon, Mammalian Gene Collection (MGC) cDNA Library, and human and mouse CRISPR/Cas9 GeCKO v2 libraries from Addgene.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Histology lab that provides histology services in support of investigators at UMass Medical School, including routine histological preparations,special stains,immunohistochemistry,frozen sections.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Facility provides labs with media necessary for Drosophila research. Includes Low Yeast Brown Food, High Yeast Brown Food, and Yellow Food media available in narrow vials, wide vials, and bottles.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Core includes three shops: Custom Machine, Harvard Medical School SEAS Scientific Instrument and WPI Manufacturing Labs. Service include consultation, design, manufacturing, modifications, and instrument repairs.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Core for full DNA and RNA analysis services. Canada's largest integrated provider of sequencing, genotyping and biochips services. Offers scientific community around the world genomic services in support of research in human health, agrifood, forestry and sustainable development.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Facility offers high throughput sequencing and library building services for UMass campuses and outside customers. Operates several types of Illumina next gen sequencers, and is closely integrated with PacBio Core Enterprise and Molecular Biology Core Labs.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Core to evaluate, select, and implement computational solutions for analysis of biological data.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Analytical Imaging Facility provides state of art methods in modern light and electron microscopy imaging to biomedical scientists with all levels of expertise. Available techniques include Electron microscopy: TEM, SEM, and sample preparation , Light microscopy: confocal, multiphoton, fluorescence, and bright-field imaging , Image analysis: Volocity, Imaris, Imod, Quant Center and ImageJ.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Core provides instrumentation for determination of crystal structures using X-ray diffraction techniques. System in Biotech II is comprised of RU300HR X-ray generator, Osmic optics, MAR Image Plate System and Oxford liquid nitrogen cryogenic crystal cooler. LRB includes MicroMax-007 HF Microfocus rotating anode X-ray generator, Osmic optics and Saturn HG CCD detector mounted on AFC11 4-axis goniometer. Sample crystals can be cooled to -180˚C with CSCOBRA Cryogenic system. This system permits very rapid and accurate diffraction data collection.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Facility provides flow cytometric analysis and cell sorting services. Located on 6th floor of E building in room E6014, consists of lab space, complete with fume hood, centrifuge, and sink space and has instruments available for cellular analysis and cell sorters.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Core offers light microscopy platforms providing guidance to researchers with their projects from sample preparation to data analysis, expertise in cellular imaging including live cell imaging, FRAP, Fluorescence Lifetime Imaging Microscopy (FLIM), FRET, FCS, image correlation spectroscopy, TIRF, spectral imaging, lattice lightsheet, stimulated emission depletion (STED), high content screening, cellular image analysis, and custom image analysis, consultations, image processing, image analysis and preparation of data for publication.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

CBCB Bioinformatics Data Science Core builds upon infrastructure of the Center for Bioinformatics and Computational Biology. Delaware Biotechnology Institute , Delaware Data Science Institute, and Protein Information Resource. Core helps with planning your research or analyzing your current data. Services:Consultation and Collaboration, Proposal Assistance,Training, Bioinformatics Software, Computational Hardware, Database and Web Services, Next Gen Analysis, Custom Analysis.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Resource offers range of mass spectrometry instrumentation, expertise in analysis of RNA, RNA modifications, and proteins involved in RNA metabolism/regulation, supports projects involving analysis of biomolecules, metabolites, and small synthetic molecules, provides consulting on experimental design, sample preparation and data interpretation, whole project development and grant writing contributions.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Core offers researchers multi laser and multi color flow cytometry sorters and analyzers, including spectral and imaging flow cytometers.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

Core sassist users with all their microscopic imaging needs, from the conception of idea, to final image analysis and presentation. Offers regular widefield microscopes for fluorescence and brightfield imaging, laser scanning microscopes (confocal and multiphoton), super-high resolution microscope (Zeiss Airyscan), automated high content optical microscopy, and electron microscopy.Provides access to several image analysis software packages, and image analysis workstations that are optimized for handling large amounts of imaging data. Available software include MetaMorph, MetaXpress and Imaris, Fiji/ImageJ.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth